I-Arbutinyikhemikhali yendalo efumaneka kwizityalo ezahlukeneyo ezifana ne-bearberry, i-cranberries, kunye ne-blueberries. Ifumene ingqwalasela enkulu kwishishini lokhathalelo lolusu kunye ne-cosmetic ngenxa yeempawu zayo zokwenza ulusu lube mhlophe kwaye lukhanye. Indlela esebenza ngayo imiphumo yokwenza ulusu lube mhlophe ijikeleza kumandla ayo okuthintela umsebenzi we-enzyme ebizwa ngokuba yi-tyrosinase, edlala indima ebalulekileyo kwimveliso ye-melanin - umbala onoxanduva lolusu, iinwele kunye nombala wamehlo.
Umbala wolusu umiselwa bubungakanani kunye nokusasazwa kwe-melanin eveliswa yi-melanocytes, iiseli ezikhethekileyo kumaleko we-epidermal. I-Tyrosinase yi-enzyme ephambili kwindlela yokwenziwa kwe-melanin, ekhuthaza ukuguqulwa kwe-amino acid tyrosine ibe yi-melanin precursors, ekugqibeleni ekhokelela ekwakhiweni kwee-melanin pigments. I-Arbutin inefuthe layo lokuba mhlophe ngokuyintloko ngokuthintela umsebenzi we-tyrosinase ngokukhuphisanayo.
I-Arbutin ine-glycoside bond, edibanisa iikhemikhali phakathi kwemolekyuli yeglucose kunye nemolekyuli ye-hydroquinone. I-Hydroquinone yikhompawundi eyaziwayo eneempawu zokukhanyisa ulusu, kodwa inokuba lukhuni eluswini kwaye inxulunyaniswa nemiphumo emibi enokubakho. I-Arbutin, kwelinye icala, isebenza njengendlela ethambileyo endaweni ye-hydroquinone ngelixa isabonelela ngokuthintela ngempumelelo ukuveliswa kwe-melanin.
Xa i-arbutin isetyenziswa eluswini, iyafunxwa ize ixutywe ibe yi-hydroquinone ngokusebenzisa iinkqubo ze-enzymatic. Le hydroquinone emva koko ithintela ngokukhuphisana isenzo se-tyrosinase ngokuthatha indawo yayo esebenzayo. Ngenxa yoko, iimolekyuli ze-tyrosine azinakuguqulwa ngempumelelo zibe zii-melanin precursors, nto leyo ekhokelela ekuncipheni kwemveliso ye-melanin. Oku ekugqibeleni kuphumela ekunciphiseni kancinci umbala wesikhumba, nto leyo ekhokelela kwithoni yesikhumba ekhanyayo nelinganayo.
Kubalulekile ukuqaphela ukubaukumhlophe kwe-arbutinIziphumo azikhawulezi. Ukutshintsha kolusu kuthatha malunga nenyanga, ngoko ke ukusetyenziswa rhoqo nangokude kweemveliso ezine-arbutin kuyimfuneko ukuze kubonwe utshintsho olubonakalayo kwimibala yolusu. Ukongeza, indlela esebenza ngayo i-arbutin isebenza ngakumbi ekusombululeni imiba enxulumene ne-hyperpigmentation, efana namabala obudala, amabala elanga, kunye ne-melasma, endaweni yokutshintsha umbala wolusu oqhelekileyo.
Iprofayili yokhuseleko lwe-Arbutin idla ngokunyanyekelwa ngcono kunezinye izinto ezikhanyisa ulusu, nto leyo eyenza ukuba ibe lukhetho oludumileyo kubantu abafuna ukulungisa umbala wolusu ongalinganiyo. Nangona kunjalo, iimpendulo zomntu ngamnye zinokuhluka, kwaye kuyacetyiswa ukuba wenze uvavanyo lwe-patch ngaphambi kokuba ufake iimveliso ezintsha zokhathalelo lolusu kwinkqubo yakho.
Ukuqukumbela, indlela yokwenza ulusu lube mhlophe ye-arbutin ixhomekeke kubuchule bayo bokuthintela umsebenzi we-tyrosinase, nto leyo ekhokelela ekunciphiseni imveliso ye-melanin. Ukuthintela kwayo i-tyrosinase ngokukhuphisanayo, okubangela ukuncipha kokwenziwa kwe-melanin, kuyenza ibe sisithako esithandekayo kwiimveliso zokhathalelo lolusu ezijolise kwi-hyperpigmentation kunye nethoni yolusu engalinganiyo. Njengakwezinye izithako zokhathalelo lolusu, kuyacetyiswa ukuba udibane nogqirha wesikhumba ngaphambi kokuba ungenise iimveliso ezintsha kwinkqubo yakho, ingakumbi ukuba uneengxaki ezithile zolusu okanye iimeko ezithile.
Ixesha lokuthumela: Agasti-30-2023