Yi-dihydrocomarin enetyhefu

I-Dihydrocomarin, ivumba elimnandi, elisetyenziswa kukutya, likwasetyenziswa njenge-comarin endaweni yoko, isetyenziswe njengencasa ye-cosmetic; Dibanisa i-cream, i-coconut, incovo yaseCinamon; Ikwasetyenziswa njenge-incavo yecuba.

Yi-dihydrocomarin enetyhefu

I-Dihydrocoumarin ayinatyhefu. I-Dihydrocoumarin yimveliso yendalo efumaneka kwi-van ye-vaning vaninoceros. Ilungiselelwe i-hydrogenation ye-comarin phambi kweNickel Catalyst nge-160-200 ○ kwaye phantsi koxinzelelo. Ingasetyenziswa kwakhona njengezinto ezingafunekiyo, i-hydrolyzed kwi-alkaline Askali AcidlPOlPOIC Acid, i-Denedration, ivaliwe-ivaliwe.

Imeko yokugcina

Ivaliwe kwaye imnyama, igcinwe kwindawo epholileyo neyomileyo, indawo ese-Barrel incinci kangangoko iphantsi kwemvume yokhuseleko, kwaye izaliswe kukhuselo lwe-nitrogen. Gcina kwindawo epholileyo yendawo epholileyo. Hlala kude nomlilo, amanzi. Kufuneka igcinwe ngokwahlukeneyo kwi-oxidizer, ungayidibanisi. Ixhotywe ngeentlobo ngeentlobo kunye nenani lezixhobo zomlilo.

Kwisifundo seVitro

Kwi-vitro e-Assay, i-Dihydrocoumarin yabangelwa kukuthintelwa kokugxininiswa kwe-SIRT1 (i-IC50 ye-208μm). Ukuncitshiswa komsebenzi we-Deacellylase ojongwayo nakwi-Doses ye-micromore (85 ± 5.8 kunye ne-73% ye-13,7m kunye ne-8μm, ngokulandelelana). I-Microtubule Sirt2 Deacestylase yathintelwa ngendlela efanayo yedosi exhomekeke (i-IC50 ye-295μm).

Emva kweeyure ezingama-24 zokuvezwa, i-Dihydrocoumarin (1-5mm) yanyusa i-cytotocity kwimigca ye-TK6 ngendlela exhomekeke kwidosi. I-Dihydrocoumarin (i-1-5mm) yanyusa i-Apoptosis kwimigca ye-TK6 ngendlela exhomekeke kwi-DEK6 kwindawo ye-6 yeeyure. Idosi ye-5mm yeDihydrocomarin yanda i-Apoptosis kwixesha le-6 leyure kwi-TK6 lesel. Emva kwexesha lokuvezwa ngama-24 iiyure, i-Dihydrocoumarin (i-1-5mm) inyuke i-P53 LYSIIN 373 ne-382 i-icethatyng ngendlela exhomekeke kwi-DK6 i-TK6 i-TK6 umgca.