Umahluko phakathi kwe-α-arbutin kunye ne-β-arbutin

i-α-arbutinkunye ne-β-arbutin ziikhemikhali ezimbini ezinxulumeneyo ezisetyenziswa rhoqo kwiimveliso zokhathalelo lolusu ukuze zikhanyise kwaye zikhanyise ulusu. Nangona zabelana ngesakhiwo esiphambili kunye nendlela yokusebenza efanayo, kukho umahluko omncinci phakathi kwezi zimbini onokuchaphazela ukusebenza kwazo kunye nemiphumo emibi enokubakho.

Ngokwesakhiwo, zombini i-α-arbutin kunye ne-β-arbutin zii-glycosides ze-hydroquinone, oko kuthetha ukuba zinemolekyuli yeglucose enamathele kwimolekyuli ye-hydroquinone. Oku kufana kwesakhiwo kuvumela zombini ezi zinto ukuba zithintele i-enzyme i-tyrosinase, ebandakanyeka kwimveliso ye-melanin. Ngokuthintela i-tyrosinase, ezi zinto zinokunceda ukunciphisa imveliso ye-melanin, nto leyo ekhokelela kwibala lolusu elikhanyayo nelilinganayo.

Umahluko ophambili phakathi kwe-α-arbutin kunye ne-β-arbutin ukwindawo ye-glycosidic bond phakathi kwe-glucose kunye ne-hydroquinone:

I-α-arbutin: Kwi-α-arbutin, i-glycosidic bond incamatheliswe kwindawo ye-alpha yeringi ye-hydroquinone. Le ndawo ibekwa kuyo ikholelwa ukuba inyusa uzinzo kunye nokunyibilika kwe-α-arbutin, okwenza ukuba isebenze ngakumbi ekusetyenzisweni kwesikhumba. I-glycosidic bond ikwanciphisa amandla okunyibilika kwe-hydroquinone, nto leyo enokukhokelela ekwakhiweni kweekhompawundi ezimnyama ezichasene nesiphumo esifunekayo sokukhanyisa ulusu.

I-β-arbutin: Kwi-β-arbutin, i-glycosidic bond inamathele kwindawo ye-beta yeringi ye-hydroquinone. Nangona i-β-arbutin ikwasebenza ekuthinteleni i-tyrosinase, isenokungazinzi kangako kune-α-arbutin kwaye ithambekele ngakumbi kwi-oxidation. Le oxidation inokubangela ukwenziwa kweekhompawundi ezimdaka ezingafunekiyo kakhulu ekukhanyiseni ulusu.

Ngenxa yokuzinza kwayo okukhulu kunye nokunyibilika kwayo, i-α-arbutin idla ngokuthathwa njengeyona ndlela isebenzayo nekhethwayo yokunyamekela ulusu. Kukholelwa ukuba inika iziphumo ezingcono zokukhanyisa ulusu kwaye ayinakwenzeka ukuba ibangele ukutshintsha kombala okanye iziphumo ebezingalindelekanga.

Xa ucinga ngeemveliso zokhathalelo lolusu eziqulethei-arbutin, kubalulekile ukufunda ilebheli yezithako ukuze ubone ukuba i-α-arbutin okanye i-β-arbutin ziyasetyenziswa na. Nangona zombini ezi zinto zisebenza kakuhle, i-α-arbutin ithathwa njengolona khetho lubalaseleyo ngenxa yokuzinza kwayo okuphuculweyo kunye namandla ayo.

Kubalulekile ukuqaphela ukuba ubuthathaka bolusu lomntu ngamnye bunokwahluka. Abanye abantu banokufumana iziphumo ebezingalindelekanga ezifana nokurhawuzelelwa lusu okanye ukuba bomvu xa besebenzisa iimveliso ezine-arbutin. Njengakwezinye izithako zokhathalelo lolusu, kuyacetyiswa ukuba wenze uvavanyo lwe-patch ngaphambi kokuba uyisebenzise kwindawo enkulu yolusu kwaye udibane nogqirha wesikhumba ukuba unenkxalabo malunga neziphumo ezinokubakho.

Ukuqukumbela, zombini i-α-arbutin kunye ne-β-arbutin zii-glycosides ze-hydroquinone ezisetyenziselwa iziphumo zazo zokukhanyisa ulusu. Nangona kunjalo, ukubeka kwe-α-arbutin i-glycosidic bond kwindawo ye-alpha kuyinika uzinzo olukhulu kunye nokunyibilika, nto leyo eyenza ukuba ibe lolona khetho luthandwayo kwiimveliso zokhathalelo lolusu ezijolise ekunciphiseni i-hyperpigmentation kunye nokufezekisa ithoni yolusu elinganayo.