I-formaldehyde kunye ne-glutaraldehydeZombini iiarhente zeekhemikhali ezisetyenziswa njengeearhente ezidibanisayo kwizicelo ezahlukeneyo, ngakumbi kwimimandla yebhayoloji, ikhemistri, kunye nesayensi yezixhobo.Ngelixa basebenzela iinjongo ezifanayo ekudibaniseni ii-biomolecules kunye nokugcina iisampuli zebhayoloji, zineempawu zekhemikhali ezahlukileyo, ukusebenza kwakhona, ubuthi, kunye nokusetyenziswa.
Ukufana:
I-Crosslinking Agents: Zombini i-formaldehyde kunyeI-glutaraldehyde yi-aldehyde, oku kuthetha ukuba baneqela le-carbonyl (-CHO) ekupheleni kwesakhiwo sabo se-molecular.Umsebenzi wabo oyintloko kukwenza iibhondi ezidibeneyo phakathi kwamaqela asebenzayo e-biomolecules, okukhokelela ekudibaniseni.I-Crosslinking ibalulekile ekuzinziseni ukwakheka kweesampulu zebhayoloji, zizenze zomelele kwaye zixhathise ukuthotywa.
Izicelo zeBiomedical: Zombini i-formaldehyde kunye ne-glutaraldehyde zifumana ukusetyenziswa okubalulekileyo kwintsimi ye-biomedical.Ngokuqhelekileyo zisetyenziselwa ukulungiswa kwezicubu kunye nokugcinwa kwi-histology kunye nezifundo ze-pathology.Izicubu ezinqamlekileyo zigcina ingqibelelo yazo yesakhiwo kwaye zinokuqhutyelwa phambili kwiinjongo ezahlukeneyo zokuhlalutya kunye nokuxilonga.
Ulawulo lweMicrobial: Zombini ii-agent zineempawu zokulwa neentsholongwane, zibenza baxabiseke kwiinkqubo zokubulala iintsholongwane kunye neenkqubo zokuvala inzala.Banokwenza iibhaktheriya, iintsholongwane, kunye nomngundo zingasebenzi, ukunciphisa umngcipheko wosulelo kwiindawo zaselabhoratri kunye nezixhobo zonyango.
Izicelo zoShishino: Zombini i-formaldehyde kunyeiglutaraldehydezisetyenziswa kwimizi-mveliso eyahlukeneyo.Baqeshwa ekuveliseni izinto zokuncamathelisa, iintlaka, iipolymers, kunye nakwimizi-mveliso yesikhumba neyolukiweyo.
Umahluko:
Ubume beMichiza: Umahluko ophambili phakathi kwe-formaldehyde kunye ne-glutaraldehyde ilele kwizakhiwo zabo zeemolekyuli.I-formaldehyde (CH2O) yeyona aldehyde ilula, yenziwe yiathom yekhabhoni enye, iiathom ezimbini zehydrogen, kunye neathom yeoksijini enye.I-Glutaraldehyde (C5H8O2), ngakolunye uhlangothi, i-aliphatic aldehyde eyinkimbinkimbi, equkethe iiathom ze-carbon ezintlanu, ii-athomu ze-hydrogen ezisibhozo, kunye ne-athomu ezimbini ze-oksijini.
Ukusebenza kwakhona: I-Glutaraldehyde idla ngokusebenza ngakumbi kune-formaldehyde ngenxa yekhonkco elide lekhabhoni.Ubukho beeathom zekhabhoni ezintlanu kwi-glutaraldehyde kuvumela ukuba ibhuloho imigama emide phakathi kwamaqela asebenzayo kwii-biomolecules, ekhokelela ekunqumleni ngokukhawuleza nangokufanelekileyo.
I-Crosslinking Efficiency: Ngenxa yokusebenza kwayo okuphezulu, i-glutaraldehyde ihlala isebenza ngakumbi ekudibaniseni ii-biomolecules ezinkulu, ezifana neeprotheni kunye ne-enzymes.I-formaldehyde, ngelixa ikwazi ukunqumla, inokufuna ixesha elingakumbi okanye ugxininiso oluphezulu ukuphumeza iziphumo ezithelekisekayo kunye neemolekyuli ezinkulu.
Ubuthi: I-Glutaraldehyde yaziwa njengetyhefu ngakumbi kune-formaldehyde.Ukuvezwa ixesha elide okanye okubalulekileyo kwi-glutaraldehyde kunokubangela ukucaphuka kwesikhumba kunye nokuphefumla, kwaye kuthathwa njengesensitizer, oku kuthetha ukuba kunokukhokelela ekuphenduleni kwabanye abantu.Ngokwahlukileyo koko, i-formaldehyde yi-carcinogen eyaziwa kakhulu kwaye ibeka imingcipheko yempilo, ngakumbi xa ifakwe umoya okanye idibene nolusu.
Ukusetyenziswa: Nangona zombini iikhemikhali zisetyenziselwa ukulungiswa kwezicubu, zihlala zikhethwa kwiinjongo ezahlukeneyo.I-formaldehyde iqhele ukusetyenziselwa ukusetyenziswa kwe-histological yesiqhelo kunye nokuqhola, ngelixa i-glutaraldehyde ifaneleka ngakumbi ukugcina izakhiwo zeselula kunye neendawo ze-antigenic kwi-electron microscopy kunye nezifundo ze-immunohistochemical.
Ukuzinza: I-formaldehyde iguquguquka kakhulu kwaye ithanda ukuphuphuma ngokukhawuleza kune-glutaraldehyde.Le propati inokuchaphazela iimfuno zokuphatha kunye nokugcinwa kwee-agent ezidibanisayo.
Isishwankathelo, i-formaldehyde kunye ne-glutaraldehyde yabelana ngeempawu eziqhelekileyo njenge-agent e-crosslinking, kodwa zihluke kakhulu kwizakhiwo zazo zeekhemikhali, ukuphinda kusebenze, ubuthi, kunye nokusetyenziswa.Ukuqonda okufanelekileyo kwezi mahluko kubalulekile ekukhetheni i-arhente edibanisayo efanelekileyo ngeenjongo ezithile kunye nokuqinisekisa usetyenziso olukhuselekileyo nolusebenzayo kwiimeko ezahlukeneyo zenzululwazi, ezonyango, kunye nezoshishino.
Ixesha lokuposa: Jul-28-2023