Apha ngezantsi kukho intshayelelo emfutshane malunga neendlela zentshukumo, iintlobo kunye novavanyo lwesalathiso seendlela ezahlukeneyo zokulondolozwa.
1.Indlela yokusebenza iyonke yeizigcini
I-preservative zi-arhente zeekhemikhali ezinceda ukubulala okanye ukuthintela imisebenzi ye-microorganisms kwizinto zokuthambisa kunye nokugcina umgangatho uwonke wezinto zokuthambisa ngexesha elide.
Nangona kunjalo, kufuneka kuqatshelwe ukuba i-preservatives ayinayo i-bactericide 鈥 ayinayo impembelelo enamandla ye-bactericidal, kwaye isebenza kuphela xa isetyenziswe ngobuninzi obaneleyo okanye xa idibene ngokuthe ngqo kunye ne-microorganisms.
Izithinteli zinqanda ukukhula kwe-microbial zithintela ukuhlanganiswa kwee-enzymes ze-metabolic ezibalulekileyo kunye nokuthintela ukuhlanganiswa kweeprotheni kumacandelo abalulekileyo eseli okanye ukuhlanganiswa kwe-nucleic acid.
2.Izinto ezichaphazela iMisebenzi yeziGcini
Zininzi izinto ezifak’ isandla kwimpembelelo yezithinteli.Ziquka;
a.Isiphumo se-pH
Utshintsho kwi-pH lunegalelo ekuqhekekeni kwezinto ezigcina i-asidi ephilayo, kwaye ngoko kuchaphazela ukusebenza kakuhle kwezinto ezigcinayo.Thatha umzekelo, kwi-pH 4 kunye ne-pH 6, i-2-bromo-2-nitro-1,3-propanediol izinzile kakhulu.
b.Iziphumo zejeli kunye neengqungquthela eziqinileyo
I-Koalin, i-magnesium silicate, i-aluminium njl njl, ngamanye amasuntswana omgubo akhoyo kwezinye izithambiso, ezidla ngokufunxa i-preservative kwaye zikhokelela ekulahlekelweni komsebenzi ngumgcini.Noko ke, ezinye zikwasebenza kakuhle ekufunxeni iintsholongwane ezifumaneka kwisithinteli.Kwakhona, ukudibanisa i-polymer gel e-soluble yamanzi kunye ne-preservative igalelo ekunciphiseni ukuxinwa kwe-residual ye-preservative kwi-cosmetics formulation, kwaye oku kunciphise umphumo we-preservative.
c.Isiphumo se-Solubilization yee-nonionic surfactants
I-solubilization yee-surfactants ezahlukeneyo ezifana ne-nonionic surfactants kwizikhuselo nazo zichaphazela umsebenzi opheleleyo wolondolozo.Nangona kunjalo, ii-oil-soluble nonionic surfactants ezifana ne-HLB=3-6 zaziwa zinamandla aphezulu okucima kwizithinteli xa kuthelekiswa ne-soluble nonionic surfactants enexabiso eliphezulu le-HLB.
d.Isiphumo sokonakala kwesithintelo
Kukho ezinye izinto ezifana nokufudumeza, ukukhanya njl., ezijongene nokubangela ukuwohloka kwezinto ezigcinayo, ngaloo ndlela kubangele ukunciphisa umphumo wabo we-antiseptic.Ngaphezu koko, ezinye zezi ziphumo zikhokelela kwimpendulo ye-biochemical ngenxa yokubulala iintsholongwane ngemitha kunye nokubulala iintsholongwane.
e.Eminye imisebenzi
Ngokufanayo, ezinye izinto ezifana nobukho be-flavour kunye ne-chelating agents kunye nokuhanjiswa kwezinto ezigcinwe kwi-oyile-amanzi kwisigaba sesibini kuya kuba negalelo ekunciphiseni umsebenzi wokukhusela kwinqanaba elithile.
3.Iipropati ze-antiseptic ze-preservatives
Iimpawu ze-antiseptic ze-preservatives zifanelekile ukuba ziqwalaselwe.Ukuba nezilondolozo ezigqithisileyo kwizithambiso ngokuqinisekileyo ziya kucaphukisa, ngelixa ukunqongophala koxinzelelo kuya kuchaphazela i-antiseptic.iipropathi zezigcini.Eyona ndlela ingcono yokuvavanya oku kukusebenzisa uvavanyo lomngeni lwebhayoloji olubandakanya ubuncinci boxinzelelo lwe-inhibitory (MIC) kunye novavanyo lwendawo yothintelo.
Uvavanyo lwesangqa se-Bacteriostatic: Olu vavanyo lusetyenziselwa ukufumanisa ezo bhaktheriya kunye nokungunda ngokukwazi ukukhula ngokukhawuleza emva kokulinywa kwindawo efanelekileyo.Kwimeko apho i-disc yephepha lokucoca elifakwe kwi-preservative liwela phakathi kweplate ephakathi kwenkcubeko, kuya kubakho isangqa se-bacteriostatic esakhiwe ngeenxa zonke ngenxa yokungena kwe-preservative.Xa ulinganisa i-diameter yesangqa se-bacteriostatic, inokusetyenziswa njenge-yardstick ukumisela ukusebenza kwe-preservative.
Ngale nto, kunokuthiwa isangqa se-bacteriostatic usebenzisa indlela yephepha kunye nobubanzi> = 1.0mm iyasebenza kakhulu.I-MIC ibizwa ngokuba yeyona nto incinci yogcino olunokongezwa kwindawo ephakathi ukuthintela ukukhula kwentsholongwane.Kwimeko enjalo, i-MIC encinci, inamandla kwiipropati ze-antimicrobial ze-preservative.
Amandla okanye umphumo womsebenzi we-antimicrobial udla ngokubonakaliswa ngendlela ye-minimum inhibitory concentration (MIC).Ngokwenza njalo, umsebenzi onamandla we-antimicrobial umiselwa lixabiso elincinci le-MIC.Nangona i-MIC ingasetyenziselwa ukwahlula phakathi komsebenzi we-bactericidal kunye ne-bacteriostatic, ii-surfactants ziyaziwa ngokubanzi ukuba zinefuthe le-bacteriostatic kwi-concentration ephantsi kunye nesiphumo sokuvala inzala kwi-concentration ephezulu.
Ngokwenyani, ngamaxesha ahlukeneyo, le misebenzi mibini iyenzeka ngexesha elinye, kwaye oku kwenza kube nzima ukwahlulahlula.Ngesi sizathu, bahlala benikwa igama elidibeneyo njenge-antimicrobial disinfection okanye ngokulula ukubulala iintsholongwane.
Ixesha lokuposa: Jun-10-2021