I-Chlorphenesin

I-Chlorphenesin(104-29-0), igama lekhemikhali yi-3-(4-chlorophenoxy)propane-1,2-diol, ngokubanzi yenziwa yi-reaction ye-p-chlorophenol kunye ne-propylene oxide okanye i-epichlorohydrin. Yiarhente ye-antiseptic kunye ne-antibacterial ene-spectrum ebanzi, enefuthe le-antiseptic kwi-Gram-positive bacteria, i-Gram-negative bacteria, i-yeast kunye ne-molds. Ivunyiwe ukuba isetyenziswe kwi-cosmetics ngamazwe amaninzi kunye nemimandla efana neYurophu, i-United States, iJapan, kunye neTshayina. Umda wokusetyenziswa ovunyiweyo yimithetho nemigaqo emininzi yelizwe yi-0.3%.
I-ChlorphenesinEkuqaleni yayingasetyenziswanga njengesigcini, kodwa njengesixhobo sokuthintela amasosha omzimba esinxulumene ne-antigen esithintela ukukhululwa kwe-histamine ebangelwa yi-IgE kwishishini lamayeza. Ngamafutshane, ilwa ne-allergy. Kwasekuqaleni kowe-1967, ishishini lamayeza lalifunde ukusetyenziswa kwe-chlorphenesin kunye ne-penicillin ukuthintela iimpembelelo ze-allergy ezibangelwa yi-penicillin. Kwakungekho kude kube ngu-1997 apho i-chlorphenesin yafunyanwa ngamaFrentshi ngenxa yeziphumo zayo zokubulala iintsholongwane kunye ne-bacteriostatic kwaye yafaka isicelo seepatenti ezinxulumene noko.
1. Ingaba i-chlorphenesin iyaphumza izihlunu?
Ingxelo yovavanyo ibonise ngokucacileyo ukuba isithako sobuhle i-chlorphenesin asinasiphumo sokukhulula izihlunu. Kwaye sikhankanyiwe amaxesha amaninzi kwingxelo: Nangona isifinyezo sesiNgesi sesithako sonyango i-chlorphenesin kunye nesithako sobuhle i-chlorphenesin zombini ziyi-Chlorphenesin, akufuneki zidideke zombini.
2. Ingaba i-chlorphenesin iyalucaphukisa ulusu?
Nokuba ngabantu okanye zizilwanyana, i-chlorphenesin ayinakurhawuzelelwa lusu xa ikwizinga eliqhelekileyo, kwaye ayisiyonto yokuthintela ulusu okanye i-photosensitizer. Kukho amanqaku amane okanye amahlanu kuphela malunga neengxelo ze-chlorphenesin ebangela ukudumba kolusu. Kwaye kukho iimeko ezimbalwa apho i-chlorphenesin esetyenzisiweyo yi-0.5% ukuya kwi-1%, idlula kakhulu uxinzelelo olusetyenziswa kwizithambiso. Kwezinye iimeko ezininzi, kukhankanyiwe kuphela ukuba i-chlorphenesin yayikwifomyula, kwaye akukho bungqina buthe ngqo bokuba i-chlorphenesin ibangela i-dermatitis. Xa kujongwa isiseko esikhulu sokusetyenziswa kwe-chlorphenesin kwizithambiso, eli thuba alinamsebenzi kangako.
3. Ngaba i-chlorphenesin iza kungena egazini?
Uvavanyo lwezilwanyana lubonise ukuba enye ye-chlorphenesin iya kungena egazini emva kokuba idibene nolusu. Uninzi lwe-chlorphenesin efunxwayo iya kugaywa kumchamo, kwaye yonke iya kukhutshwa emzimbeni kwiiyure ezingama-96. Kodwa yonke le nkqubo ayizukubangela miphumo emibi enobungozi.
4. Ngaba iChlorphenescine iyawunciphisa umzimba?
Ayizukwenzeka. I-Chlorphenesin sisithinteli-mzimba esinokutshintshwa esinxulumene ne-antigen. Okokuqala, i-chlorphenesin idlala indima ebalulekileyo kuphela xa idityaniswe ne-antigen ekhethiweyo, kwaye ayinciphisi amandla omzimba okulwa, kwaye ayinyusi izinga losulelo lwezifo. Okwesibini, emva kokuyeka ukusetyenziswa, isiphumo sokuthintela-mzimba se-antigen ekhethiweyo siya kuphela, kwaye akuyi kubakho siphumo siqhubekayo.
5. Ithini isiphelo sokugqibela sovavanyo lokhuseleko?
Ngokusekelwe kwizicelo ezikhoyo kunye noxinzelelo lokusetyenziswa eMelika (ukuhlamba nge-0.32%, uhlobo lwabahlali be-0.30%), i-FDA ikholelwa ukubai-chlorphenesinikhuselekile njengesigcini sobuhle.