I-Chlorphenesin

I-Chlorphenesin(104-29-0), igama lekhemikhali yi-3-(4-chlorophenoxy) propane-1,2-diol, ngokuqhelekileyo idityaniswe ngokusabela kwe-p-chlorophenol kunye nepropylene oxide okanye i-epichlorohydrin.I-antiseptic ebanzi kunye ne-antibacterial agent, ene-antiseptic effect kwi-Gram-positive bacteria, i-Gram-negative bacteria, yeasts kunye ne-molds.Ivunyiwe ukuba isetyenziswe kwizithambiso kumazwe amaninzi nakwimimandla efana neYurophu, iUnited States, iJapan kunye neTshayina.Umda wokusetyenziswa ovunywe yimithetho emininzi yelizwe kunye nemimiselo yi-0.3%.
I-Chlorphenesinyayingasetyenziswanga ekuqaleni njenge-preservative, kodwa njenge-antigen-related immunosuppressant evimbela ukukhutshwa kwe-histamine ye-IgE-mediated kwishishini lamachiza.Ngamafutshane, i-anti-allergies.Kwangoko ngo-1967, ishishini loxubo-mayeza lalifunde ukusetyenziswa kwe-chlorphenesin kunye ne-penicillin ukuthintela ukuchasana nokwaliwa okubangelwa yi-penicillin.Kwakungekho de kwango-1997 apho i-chlorphenesin yafunyanwa ngamaFrentshi ngenxa yeziphumo zayo zokubulala iintsholongwane kunye ne-bacteriostatic kwaye yafaka isicelo samalungelo abenzi anxulumeneyo.
1. Ngaba i-chlorphenesin ikhulula izihlunu?
Ingxelo yokuvavanya ibonise ngokucacileyo: isithako se-cosmetic chlorphenesin asinayo i-muscle-relieving effect.Kwaye ikhankanyiwe kaninzi kwingxelo: Nangona isishunqulelo sesiNgesi sesithako soxubo lwe-chlorphenesin kunye ne-cosmetic ingredient chlorphenesin zombini ziyi-Chlorphenesin, ezi zimbini akufuneki zibhideke.
2. Ngaba i-chlorphenesin iyacaphukisa ulusu?
Nokuba yeyabantu okanye izilwanyana, i-chlorphenesin ayinakucaphuka kwesikhumba kwindawo eqhelekileyo, kwaye ayisosihluzi solusu okanye ifotosensitizer.Kukho amanqaku amane kuphela okanye amahlanu malunga neengxelo zeklophenesin ezibangela ukudumba kwesikhumba.Kwaye kukho iimeko ezimbalwa apho i-chlorphenesin esetyenzisiweyo yi-0.5% ukuya kwi-1%, idlula kakhulu i-concentration esetyenziswa kwi-cosmetics.Kwezinye iimeko ezininzi, kwakhankanywa kuphela ukuba i-chlorphenesin iqulethwe kwifomula, kwaye kwakungekho bungqina bucacileyo bokuba i-chlorphenesin yabangela i-dermatitis.Ukuthathela ingqalelo isiseko esikhulu sokusetyenziswa kwe-chlorphenesin kwizinto zokuthambisa, oku kunokwenzeka akukho nto.
3. Ngaba i-chlorphenesin iya kungena egazini?
Uvavanyo lwezilwanyana lubonise ukuba enye i-chlorphenesin iya kungena egazini emva kokuba idibene nolusu.Uninzi lwe-chlorphenesin efunxayo iya kuxutywa kumchamo, kwaye yonke iya kukhutshwa emzimbeni kwiiyure ezingama-96.Kodwa yonke inkqubo ayiyi kuvelisa nayiphi na imiphumo eyingozi.
4. Ngaba i-Chlorphenescine iyakunciphisa ukugonywa?
Andizu.I-Chlorphenesin yi-antigen-related-related immunosuppressant.Okokuqala, i-chlorphenesin idlala indima efanelekileyo kuphela xa idibene ne-antigen ekhethiweyo, kwaye ayinciphisi ukhuseleko lomzimba, kwaye ayinyusi izinga losulelo lwezifo.Okwesibini, emva kokupheliswa kokusetyenziswa, i-immunosuppressive effect ye-antigen ekhethiweyo iya kunyamalala, kwaye ayiyi kuba nefuthe elizinzileyo.
5. Sithini isiphelo sokugqibela sovavanyo lokhuseleko?
Ngokusekelwe kwizicelo ezikhoyo kunye nokugxilwa kokusetyenziswa e-United States (ukuhlamba i-0.32%, uhlobo lwabahlali be-0.30%), i-FDA ikholelwa ukubachlorphenesinikhuselekile njengesigcini sezithambiso.