Njenge-aliphatic dibasic aldehyde eyomeleleyo, i-glutaraldehyde lulwelo olungenambala olucacileyo olunevumba elicaphukisayo kunye nefuthe elihle lokubulala iintsholongwane zokuzala, iintsholongwane, ii-mycobacteria, i-pathogenic mold kunye ne-bacterial bacterium, kunye ne-non-oxidizing broad-spectrum bactericide. I-Glutaraldehyde sisibulali-ntsholongwane esisebenza kakuhle esibulala iintlobo ngeentlobo zeentsholongwane kwaye sicetyiswa yi-World Health Organisation njengesibulali-ntsholongwane kwiintsholongwane ze-hepatitis.
I-Glutaraldehyde 25%Inefuthe elivuselelayo neliphilisayo kulusu lomntu kunye neenwebu ze-mucous kwaye inokubangela i-allergies, ngoko ke akufuneki isetyenziswe ekubulaleni iintsholongwane zomoya kunye nezixhobo zokutya. Ukongeza, i-glutaraldehyde akufuneki isetyenziswe ekubulaleni iintsholongwane kunye nokubulala iintsholongwane kwizixhobo zonyango ezithwala iityhubhu, iinaliti zenaliti, i-sutures zotyando kunye nemisonto yekotoni.
I-Glutaraldehyde isetyenziswa kakhulu njengesibulali-ntsholongwane kwishishini lezonyango kwaye abasebenzisi banokuba nemibuzo enxulumene nemiba yobugcisa, ngoko ke iSpringchem apha inika iingongoma ezibalulekileyo malunga ne-glutaraldehyde ukuze ubhekisele kuyo.
Aukufakelwa kwe-glutaraldehyde
I-Glutaraldehyde isetyenziswa njengesibulali-ntsholongwane esibandayo ukubulala iintsholongwane kwizixhobo ezibuthathaka kubushushu, ezifana nee-endoscopes kunye nezixhobo ze-dialysis. Isetyenziswa njengesibulali-ntsholongwane esikumgangatho ophezulu kwizixhobo zotyando ezingenako ukubulala iintsholongwane kubushushu.
I-Glutaraldehyde isetyenziswa kwiindawo ezahlukeneyo zonyango:
● Unyango lokulungisa izicubu kwiilabhoratri zezifo
● Ukubulala iintsholongwane kunye nokubulala iintsholongwane kwiindawo kunye nezixhobo
● Isixhobo sokuqinisa esisetyenziselwa ukwenza ii-X-reyi
● Ukulungiselela izicwili
Ukuphelelwa lixeshaumhla we-glutaraldehyde kunye nendlela yokuchonga ukuphelelwa kwayo
Kwiqondo lobushushu begumbi kwaye phantsi kwemeko yokuba kude nokukhanya kunye nendawo yokugcina evaliweyo, umhla wokuphelelwa kwe-glutaraldehyde akufuneki ube ngaphantsi kweminyaka emi-2, kwaye umxholo wesithako esisebenzayo se-glutaraldehyde kufuneka ube ubuncinane yi-2.0% kumhla wokuphelelwa.
Kwiqondo lobushushu begumbi, emva kokongeza i-rust inhibitor kunye ne-pH adjuster, i-glutaraldehyde isetyenziselwa ukubulala iintsholongwane okanye ukubulala iintsholongwane kwizixhobo zonyango, kwaye ingasetyenziswa iintsuku ezili-14 eziqhubekayo. Umxholo we-glutaraldehyde kufuneka ubuncinci ube yi-1.8% ngexesha lokusetyenziswa.
Ukuntywiliselwadusuleloindlelakunye ne-glutaraldehyde
Nciphisa izixhobo ezicociweyo kwisisombululo sokubulala iintsholongwane se-2.0% ~ 2.5% se-glutaraldehyde ukuze uzintywilisele ngokupheleleyo, uze ugqume isitya sokubulala iintsholongwane kubushushu begumbi imizuzu engama-60, uze uhlambe ngamanzi acocekileyo ngaphambi kokuba uyisebenzise.
Izixhobo zokuxilonga nezonyango ezicociweyo nezomileyo, izixhobo kunye nezinto ezisetyenzisiweyo zifakwa kwisisombululo se-2% se-alkaline glutaraldehyde esintywiliselwa ngokupheleleyo, kwaye amaqamza omoya aphezu kwezixhobo kufuneka asuswe ngesikhongozeli sigqunywe kubushushu obuyi-20 ~ 25℃. Ukubulala iintsholongwane kusebenza kude kube lixesha elichaziweyo lemiyalelo yemveliso.
Iimfuneko zokubulala iintsholongwane kwi-endoscopes nge-glutaraldehyde
1. Iiparamitha zokubulala iintsholongwane ezikumgangatho ophezulu kunye nokubulala iintsholongwane
● Uxinzelelo: ≥2% (i-alkaline)
● Ixesha: ixesha lokuntywiliselwa kwe-bronchoscopy ≥ imizuzu engama-20; ezinye ii-endoscopes ≥ imizuzu eli-10; ukuntywiliselwa kwe-endoscopic kwizigulana ezinesifo sephepha se-mycobacterium, ezinye ii-mycobacteria kunye nezinye izifo ezikhethekileyo ≥ imizuzu engama-45; ukubulala iintsholongwane ≥ iiyure ezili-10
2. Sebenzisa indlela
● Umatshini wokucoca nokubulala iintsholongwane kwi-endoskopu
● Ukusebenza ngesandla: isibulali-ntsholongwane kufuneka sizaliswe ngombhobho ngamnye size simanziswe ukuze sibulale iintsholongwane
3. Amanyathelo okuzikhusela
I-Glutaraldehyde 25%Ayina-allergies kwaye iyacaphukisa ulusu, amehlo kunye nomoya, kwaye inokubangela i-dermatitis, i-conjunctivitis, ukudumba kwempumlo kunye ne-asthma yomsebenzi, ngoko ke kufuneka isetyenziswe kumatshini wokucoca kunye nokubulala iintsholongwane kwi-endoscope.
Amanyathelo okuzikhusela nge-glutaraldehyde
I-Glutaraldehyde iyacaphukisa ulusu kunye ne-mucous membranes kwaye iyingozi ebantwini, kwaye isisombululo se-glutaraldehyde sinokubangela umonakalo omkhulu emehlweni. Ke ngoko, kufuneka silungiswe kwaye sisetyenziswe kwindawo enomoya ococekileyo, ukhuseleko lomntu ngamnye kufuneka lulungiswe kakuhle, njengokunxiba iimaski zokukhusela, iiglavu zokukhusela kunye neeglasi zokukhusela. Ukuba ichukunyiswe ngengozi, kufuneka ihlanjwe ngamanzi ngoko nangoko nangokuqhubekayo, kwaye kufuneka kufunwe unyango kwangethuba ukuba amehlo enzakele.
Ifanele isetyenziswe kwindawo enomoya ococekileyo, kwaye ukuba kuyimfuneko, indawo leyo mayibe nezixhobo zokukhupha umoya. Ukuba uxinzelelo lwe-glutaraldehyde emoyeni kwindawo esetyenziswa kuyo luphezulu kakhulu, kucetyiswa ukuba ixhotyiswe ngezixhobo zokuphefumla ezizimeleyo (imaski yokukhusela uxinzelelo). Izikhongozeli ezisetyenziselwa ukuntywila kufuneka zicoceke, zigqunywe kwaye zihlanjululwe iintsholongwane ngaphambi kokuba zisetyenziswe.
Ukujonga rhoqo ukuxinana kwe-glutaraldehyde
Uxinzelelo olusebenzayo lwe-glutaraldehyde lunokuhlolwa ngemicu yovavanyo lweekhemikhali.
Kwinkqubo yokusetyenziswa rhoqo, kufuneka kuqatshelwe imihla ngemihla ukuze kuqondwe utshintsho ekugxilweni kwayo, kwaye akufuneki isetyenziswe xa uxinzelelo lwayo lufunyenwe lungaphantsi koxinzelelo olufunekayo.
Kufuneka kuqinisekiswe ukuba ubuninzi beglutaraldehyde esetyenziswayo buhlangabezana neemfuno zencwadana yemveliso.
Ngaba kufanelei-glutaraldehyde mayivulwe ngaphambi kokusetyenziswa?
Isisombululo samanzi se-glutaraldehyde sine-asidi kwaye sidla ngokungazibulali ii-spores ezikhula ngokukhawuleza kwimeko ye-asidi. Kuphela xa isisombululo "sisebenza" yi-alkalinity ukuya kwixabiso le-pH eliyi-7.5-8.5 apho sinokubulala ii-spores. Nje ukuba sisebenze, ezi zisombululo zinobomi beshelufu ubuncinane beentsuku ezili-14. Kumanqanaba e-alkaline pH, iimolekyuli ze-glutaraldehyde zivame ukuba yi-polymerize. Ukwenziwa kwe-polymerize ye-glutaraldehyde kuphumela ekuvalweni kweqela le-aldehyde kwindawo esebenzayo yemolekyuli yayo ye-glutaraldehyde enoxanduva lokubulala ii-spores ezikhula ngokukhawuleza, kwaye ngaloo ndlela isiphumo se-bactericidal siyancitshiswa.
Izinto ezichaphazela ukubulala iintsholongwane kwi-glutaraldehyde
1. Ixesha lokugxila kunye nesenzo
Isiphumo sokulwa neentsholongwane siya kuphucuka ngokwanda koxinzelelo kunye nokwandiswa kwexesha lokusebenza. Nangona kunjalo, isisombululo se-glutaraldehyde esineqhekeza lobunzima elingaphantsi kwe-2% asinakufikelela kwisiphumo esithembekileyo sokulwa neentsholongwane kwii-spores zebhaktiriya, nokuba singalwandisa njani ixesha lokulwa neentsholongwane. Ke ngoko, kuyimfuneko ukusebenzisa isisombululo se-glutaraldehyde esineqhekeza lobunzima elingaphezulu kwe-2% ukubulala ii-spores zebhaktiriya.
2. Isisombululo se-asidi kunye ne-alkalinity
Isiphumo sokubulala iintsholongwane se-acid glutaraldehyde siphantsi kakhulu kunese-alkaline glutaraldehyde, kodwa umahluko uya kuncipha kancinci kancinci xa amaqondo obushushu enyuka. Kuluhlu lwe-pH 4.0-9.0, isiphumo sokubulala iintsholongwane siyanda xa i-pH inyuka; isiphumo sokubulala iintsholongwane esinamandla sibonwa kwi-pH 7.5-8.5; xa i-pH ingaphezulu kwe-9, i-glutaraldehyde ipholime ngokukhawuleza kwaye isiphumo sokubulala iintsholongwane siphela ngokukhawuleza.
3. Ubushushu
Ikwanayo nefuthe lokubulala iintsholongwane xa kubushushu obuphantsi. Isiphumo sokubulala iintsholongwane se-glutaraldehyde siyanda xa kubushushu, kwaye i-coefficient yayo yobushushu (Q10) yi-1.5 ukuya kwi-4.0 kwi-20-60℃.
4. Izinto eziphilayo
Izinto eziphilayo zenza isiphumo sokubulala iintsholongwane sibe buthathaka, kodwa isiphumo sezinto eziphilayo kwisiphumo sokubulala iintsholongwane se-glutaraldehyde sincinci kunezinye izibulali-ntsholongwane. I-20% ye-calf serum kunye ne-1% yegazi elipheleleyo azinampembelelo kwisiphumo sokubulala iintsholongwane se-2% ye-glutaraldehyde.
5. Isiphumo sokusebenzisana kwee-surfactants ezingezizo ii-ionic kunye nezinye izinto ze-physicochemical
I-Polyoxyethylene fatty alcohol ether ayisiyo-ionic surfactant, kwaye uzinzo kunye nesiphumo se-bactericidal ziphuculwe kakhulu ngokongeza i-0.25% polyoxyethylene fatty alcohol ether kwisisombululo se-glutaraldehyde esenziwe nge-acid-base glutaraldehyde ephuculweyo. I-Ultrasound, imisebe ye-far infrared kunye ne-glutaraldehyde zinefuthe lokubulala iintsholongwane ngokusebenzisana.
ISpringchem, umvelisi we-glutaraldehyde ophambili eTshayina, ubonelela nge-glutaraldehyde engama-25% kunye nama-50% kwiinjongo zoshishino, elebhu, ezolimo, ezonyango, kunye nezinye izinto zasekhaya, ikakhulu ekubulaleni iintsholongwane kunye nokubulala iintsholongwane kumphezulu nezixhobo. Ukuze ufumane naluphi na ulwazi oluthe vetshe, nxibelelana nathi.
Ixesha lokuthumela: Agasti-16-2022