Njenge-saturated straight-chain aliphatic dibasic aldehyde, i-glutaraldehyde lulwelo olungenambala olungenambala olunevumba elicaphukisayo kunye nesiphumo esibalaseleyo sokubulala kwiibhaktheriya zokuzala, iintsholongwane, i-mycobacteria, ukungunda kwe-pathogenic kunye nebhaktiriya yebhaktiriya, kunye ne-non-oxidizing-spectrum bactericide.I-Glutaraldehyde sisibulali-ntsholongwane esisebenza kakhulu esibulala iintlobo ngeentlobo zeentsholongwane kwaye icetyiswa nguMbutho wezeMpilo weHlabathi njengesibulali ntsholongwane kwintsholongwane ye-hepatitis.
IGlutaraldehyde 25%ineziphumo ezivuselelayo kunye nokunyanga eluswini lomntu kunye ne-mucous membranes kwaye inokubangela ukungezwani komzimba, ngoko ke akufanele isetyenziselwe ukubulala iintsholongwane emoyeni kunye nezixhobo zokutya.Ukongeza, i-glutaraldehyde akufuneki isetyenziselwe ukubulala iintsholongwane kunye nokubulala inzala kwezixhobo zonyango ze-tubular, iinaliti zenaliti, iisutures zotyando kunye nemisonto yomqhaphu.
I-Glutaraldehyde isetyenziswa ngokuqhelekileyo njenge-disinfectant kwishishini lezonyango kwaye abasebenzisi banokuba nemibuzo enxulumene nemiba yobugcisa, ngoko ke i-Springchem apha inikezela ngeengongoma eziphambili malunga ne-glutaraldehyde kwireferensi yakho.
Aukusetyenziswa kwe-glutaraldehyde
I-Glutaraldehyde isetyenziswa njenge-sterilant ebandayo yokubulala iintsholongwane kwizixhobo ezithintela ukushisa, ezifana ne-endoscopes kunye nezixhobo ze-dialysis.Isetyenziswa njengesibulali-ntsholongwane esikwinqanaba eliphezulu kwezo zixhobo zotyando ezingakwaziyo ukuvalelwa bubushushu.
IGlutaraldehyde isetyenziselwa izicelo ezininzi kwiindawo zempilo:
● Isixhobo sokulungisa izicubu kwiilebhu ze-pathology
● Isibulali-ntsholongwane kunye nokuvalwa komgangatho kunye nezixhobo
● Isixhobo sokuqina esisetyenziswa ukwenza iiX-reyi
● Ukulungiselela uxhulumaniso
Ukuphelelwa lixeshaumhla we-glutaraldehyde kunye nendlela yokumisela ukuphelelwa yisikhathi
Kwiqondo lokushisa lokushisa kunye naphantsi kwemeko yokuba kude nokukhanya kunye nokugcinwa okutywiniweyo, umhla wokuphelelwa yisikhathi kwe-glutaraldehyde akufanele ube ngaphantsi kweminyaka eyi-2, kwaye umxholo osebenzayo we-glutaraldehyde kufuneka ube ubuncinane kwi-2.0% ngexesha lokuphelelwa yisikhathi.
Kwiqondo lokushisa lokushisa, emva kokufaka i-rust inhibitor kunye ne-pH adjuster, i-glutaraldehyde isetyenziselwa i-disinfection yokucwiliswa kwesixhobo sonyango okanye inzala, kwaye ingasetyenziselwa iintsuku ezili-14 eziqhubekayo.Umxholo we-glutaraldehyde kufuneka ube ubuncinane ubuncinane be-1.8% ngexesha lokusetyenziswa.
Ukuntywiliselwadusuleloindlelakunye ne-glutaraldehyde
Gcoba izixhobo ezicociweyo kwi-2.0% ~ 2.5% isisombululo se-glutaraldehyde disinfection ukuze uzifake ngokupheleleyo, uze ugubungele isitya sokubulala iintsholongwane kwindawo yokushisa kwe-60 min, kwaye uhlambulule ngamanzi angcolileyo ngaphambi kokusetyenziswa.
Izixhobo zokuxilonga ezicociweyo nezomisiweyo kunye nezixhobo zonyango, izixhobo kunye namanqaku afakwe kwi-2% yesisombululo se-alkaline glutaraldehyde efakwe ngokupheleleyo, kwaye amaqamza omoya phezu kwezixhobo kufuneka asuswe kunye nesitya esigqunywe kwiqondo lokushisa lika-20 ~ 25 ℃.I-disinfection isebenza kude kube lixesha elichaziweyo lemiyalelo yemveliso.
Iimfuno zokubulala iintsholongwane kwi-endoscopes nge-glutaraldehyde
1. Izinga eliphezulu lokubulala iintsholongwane kunye neeparamitha zokuvala inzala
● Ugxininiso: ≥2% (alkaline)
● Ixesha: ixesha lokucwiliswa kwe-bronchoscopy disinfection ≥ 20min;ezinye ii-endoscopes disinfection ≥ 10min;ukucwiliswa kwe-endoscopic kwizigulane ezine-mycobacterium tuberculosis, ezinye i-mycobacteria kunye nezinye izifo ezikhethekileyo ≥ 45min;inzala ≥ 10h
2. Sebenzisa indlela
● Ukucoca i-endoskophu kunye nomatshini wokubulala iintsholongwane
● Ukusebenza ngesandla: isibulala-ntsholongwane kufuneka sigcwaliswe ngombhobho ngamnye kwaye sifakwe kwi-disinfectant
3. Izilumkiso
IGlutaraldehyde 25%i-allergenic kwaye iyacaphukisa ulusu, amehlo kunye nokuphefumula, kwaye inokubangela i-dermatitis, i-conjunctivitis, ukuvuvukala kweempumlo kunye ne-asthma yomsebenzi, ngoko kufuneka isetyenziswe kumatshini wokucoca i-endoscope kunye ne-disinfection.
Izilumkiso kunye ne-glutaraldehyde
I-Glutaraldehyde iyacaphukisa ulusu kunye ne-mucous membranes kunye netyhefu ebantwini, kwaye isisombululo se-glutaraldehyde sinokubangela umonakalo omkhulu emehlweni.Ngoko ke, kufuneka ilungiswe kwaye isetyenziswe kwindawo enomoya, ukukhuselwa komntu kufuneka kulungiswe kakuhle, njengokugqoka iimaski ezikhuselayo, iiglavu zokukhusela kunye neeglasi zokukhusela.Ukuba kuqhagamshelwane nayo kungaqondanga, ifanele igungxulwe ngokukhawuleza nangokuqhubekayo ngamanzi, yaye kufuneka kufunelwe unyango kwangethuba ukuba amehlo enzakele.
Kufuneka isetyenziswe kwindawo engena umoya, kwaye ukuba kuyimfuneko, indawo kufuneka ibe nezixhobo zokukhupha umoya.Ukuba ukuxinwa kwe-glutaraldehyde emoyeni kwindawo yokusetyenziswa kuphezulu kakhulu, kucetyiswa ukuba uxhotyiswe ngezixhobo zokuphefumla ezizimeleyo (i-mask ekhuselayo yoxinzelelo).Izikhongozeli ezisetyenziselwa izixhobo zokumanzisa kufuneka zicoceke, zogqunywe kwaye zibulawe iintsholongwane phambi kokuba zisetyenziswe.
Ukubeka iliso rhoqo kwi-glutaraldehyde concentration
Ukugxininiswa okusebenzayo kwe-glutaraldehyde kunokujongwa ngeentambo zokuvavanya iikhemikhali.
Kwinkqubo yokusetyenziswa ngokuqhubekayo, ukubeka iliso kwansuku zonke kufuneka kuqiniswe ukuqonda utshintsho lwalo, kwaye akufanele isetyenziswe xa ukugxilwa kwayo kufunyenwe ngaphantsi koxinzelelo olufunekayo.
Kufuneka kuqinisekiswe ukuba i-concentration ye-glutaraldehyde ekusebenziseni ihlangabezana neemfuno zencwadana yemveliso.
KufunekaI-glutaraldehyde kufuneka isebenze ngaphambi kokusetyenziswa?
Isisombululo se-aqueous se-glutaraldehyde si-acidic kwaye ngokuqhelekileyo asikwazi ukubulala i-spores ehlumayo kwimeko ye-acidic.Kuphela xa isisombululo "sisebenza" nge-alkalinity kwixabiso le-pH ye-7.5-8.5 ukuba inokubulala i-spores.Nje ukuba zisebenze, ezi zisombululo zineshelufu yobomi ubuncinane beentsuku ezili-14.Kumanqanaba e-alkaline pH, iimolekyuli ze-glutaraldehyde zikholisa ukwenza i-polymerize.I-polymerization ye-glutaraldehyde ibangela ukuvalwa kwendawo esebenzayo yeqela le-aldehyde ye-molecule yayo ye-glutaraldehyde ejongene nokubulala i-spores ekhulayo, kwaye ngoko umphumo we-bactericidal uyancipha.
Izinto ezichaphazela ukuvala inzala kwe-glutaraldehyde
1. Ukugxila kunye nexesha lesenzo
Impembelelo ye-bactericidal iya kunyuswa ngokunyuka koxinzelelo kunye nokwandiswa kwexesha lesenzo.Nangona kunjalo, isisombululo se-glutaraldehyde esineqhezu elikhulu elingaphantsi kwe-2% asikwazi ukufikelela kwisiphumo esithembekileyo se-bactericidal kwi-spores yebhakteria, kungakhathaliseki ukuba ukwandisa ixesha le-bactericidal.Ngoko ke, kuyimfuneko ukusebenzisa isisombululo se-glutaraldehyde kunye neqhekeza elikhulu kune-2% ukubulala iintsholongwane zebhaktheriya.
2. Isisombululo se-acidity kunye ne-alkalinity
Impembelelo ye-bactericidal ye-acid glutaraldehyde iphantsi kakhulu kune-alkaline glutaraldehyde, kodwa umahluko uya kuncipha ngokuthe ngcembe ngokunyuka kobushushu.Kuluhlu lwe-pH 4.0-9.0, umphumo we-bactericidal wanda ngokunyuka kwe-pH;impembelelo enamandla kakhulu ye-bactericidal ibonwa kwi-pH 7.5-8.5;kwi-pH> 9, i-glutaraldehyde ipholisa ngokukhawuleza kwaye umphumo we-bactericidal ulahleka ngokukhawuleza.
3. Ubushushu
Kwakhona kunempembelelo ye-bactericidal kumaqondo aphantsi.Impembelelo ye-bactericidal ye-glutaraldehyde inyuka ngobushushu, kunye ne-coefficient yayo yokushisa (Q10) yi-1.5 ukuya kwi-4.0 kwi-20-60 ℃.
4. Izinto eziphilayo
I-Organic matter yenza i-bactericidal effect ibe buthathaka, kodwa umphumo we-organic matter kwi-bactericidal effect ye-glutaraldehyde incinci kunezinye ii-disinfectants.I-20% ye-serum yethole kunye ne-1% yegazi lonke ayinayo impembelelo kwimpembelelo ye-bactericidal ye-2% ye-glutaraldehyde.
5. Impembelelo ye-Synergistic ye-nonionic surfactants kunye nezinye izinto ze-physicochemical
I-Polyoxyethylene enamafutha e-alcohol ether yi-nonionic surfactant, kwaye uzinzo kunye nefuthe le-bactericidal ziphuculwe kakhulu ngokudibanisa i-0.25% ye-polyoxyethylene enamafutha e-alcohol ether kwisisombululo se-glutaraldehyde eyenziwe nge-acid-base ephuculweyo ye-glutaraldehyde.I-Ultrasound, imisebe ye-infrared ekude kunye ne-glutaraldehyde inefuthe le-synergistic sterilization.
I-Springchem, umenzi we-glutaraldehyde waseTshayina ophezulu kwi-10, ubonelela nge-glutaraldehyde ngama-25% kunye nama-50% kwimizi-mveliso, ilabhoratri, ezolimo, ezonyango, kunye neenjongo ezithile zekhaya, ngokuyintloko ekubulaleni iintsholongwane kunye nokubulala iintsholongwane kumphezulu kunye nezixhobo.Ngolwazi oluthe vetshe, vele uqhagamshelane nathi.
Ixesha lokuposa: Aug-16-2022