Ngaba i-phenoxyethanol iyingozi eluswini?

Yintoni ii-phenoxyethanol?
I-Phenoxyethanol yi-glycol ether eyenziwe ngokudibanisa amaqela e-phenolic kunye ne-ethanol, kwaye ibonakala njengeoyile okanye i-mucilage kwimeko yayo yolwelo. Yinto esetyenziswa kakhulu kwizithambiso, kwaye inokufumaneka kuyo yonke into ukusuka kwiikhrimu zobuso ukuya kwiilotion.
I-Phenoxyethanol ifezekisa isiphumo sayo sokulondoloza kungekhona nge-antioxidant kodwa ngomsebenzi wayo wokulwa neentsholongwane, othintela kwaye ude ususe iidosi ezinkulu zeentsholongwane ezinegram kunye ne-negative. Ikwanayo nefuthe elibalulekileyo lokuthintela kwiintsholongwane ezahlukeneyo eziqhelekileyo ezifana ne-E. coli kunye ne-Staphylococcus aureus.
Ngaba i-phenoxyethanol iyingozi eluswini?
I-Phenoxyethanol inokuba yingozi xa ityiwa ngeedosi ezininzi. Nangona kunjalo, ukusetyenziswa kwayo ngaphakathii-phenoxyethanolkumanqanaba angaphantsi kwe-1.0% kusesekuluhlu olukhuselekileyo.
Ngaphambili besikhe saxoxa ngokuba ingaba i-ethanol iyaguqulwa ibe yi-acetaldehyde ngobuninzi eluswini na nokuba iyafunxwa ngobuninzi lusu. Zombini ezi zinto zibaluleke kakhulu nakwi-phenoxyethanol. Kwisikhumba esinomqobo oqinileyo, i-phenoxyethanol yenye yezona ethers ze-glycol ezitshabalalisa ngokukhawuleza. Ukuba indlela ye-metabolism ye-phenoxyethanol ifana neye-ethanol, inyathelo elilandelayo kukwenziwa kwe-acetaldehyde engaguqukiyo, kulandele i-phenoxyacetic acid kunye nezinye ii-free radicals.
Musa ukukhathazeka okwangoku! Xa besithetha nge-retinol ngaphambili, sikhankanye nenkqubo yee-enzyme enxulumene ne-metabolism ye-i-phenoxyethanol, kwaye ukuba ezi nkqubo zokuguqula zenzeka phantsi kwe-stratum corneum. Ngoko ke kufuneka sazi ukuba ingakanani i-phenoxyethanol efunxwa nge-transdermal. Kolunye uphando oluvavanye ukufunxwa kwe-sealant esekwe emanzini equlethe i-phenoxyethanol kunye nezinye izithako ezilwa neentsholongwane, ulusu lwehagu (olunokungena okusondeleleneyo nabantu) luya kufunxwa i-2% ye-phenoxyethanol, nayo eyanyuka yaya kwi-1.4% kuphela emva kweeyure ezi-6, kunye ne-11.3% emva kweeyure ezingama-28.
Ezi zifundo zibonisa ukuba ukufunxwa nokuguqulwai-phenoxyethanolkumanqanaba angaphantsi kwe-1% akwanele ukuvelisa iidosi eziyingozi zeemetabolites. Iziphumo ezifanayo zifunyenwe nakwizifundo ezisebenzisa iintsana ezisandul’ ukuzalwa ezingaphantsi kweeveki ezingama-27. Olu phononongo luthe, "Amanzii-phenoxyethanolayibangeli monakalo mkhulu eluswini xa ithelekiswa nezigcini-mveliso ezisekelwe kwi-ethanol. I-Phenoxyethanol iyangena eluswini lweentsana ezisandul’ ukuzalwa, kodwa ayenzi i-oxidation product phenoxyacetic acid ngobuninzi." Esi siphumo sibonisa ukuba i-phenoxyethanol inezinga eliphezulu le-metabolism eluswini kwaye ayibangeli monakalo mkhulu. Ukuba iintsana ziyakwazi ukumelana nayo, woyika ntoni?
Ngubani ongcono, i-phenoxyethanol okanye utywala?
Nangona i-phenoxyethanol iguqulwa ngokukhawuleza kune-ethanol, uxinaniso oluphezulu oluthintelweyo lokusetyenziswa kwe-topical luphantsi kakhulu kwi-1%, ngoko ke ayilulo uthelekiso oluhle. Ekubeni i-stratum corneum ithintela uninzi lwee-molecules ekufunxweni, ii-free radicals eziveliswa zezi zimbini zincinci kakhulu kunezo zenziwe zii-oxidation reactions zazo yonke imihla! Ngaphezu koko, kuba i-phenoxyethanol inamaqela e-phenolic ngendlela yeoyile, iyaphuma kwaye yome kancinci.
Isishwankathelo
I-Phenoxyethanol sisithinteli esiqhelekileyo esisetyenziswa kwizithambiso. Ikhuselekile kwaye isebenza kakuhle, kwaye ilandela i-parabens kuphela ngokwendlela esetyenziswa ngayo. Nangona ndicinga ukuba ii-parabens nazo zikhuselekile, ukuba ukhangela iimveliso ezingenazo ii-parabens, i-phenoxyethanol lukhetho olufanelekileyo!