Ngaba i-phenoxyethanol iyingozi eluswini?

Yintoni iphenoxyethanol?
I-Phenoxyethanol yi-glycol ether eyenziwe ngokudibanisa amaqela e-phenolic kunye ne-ethanol, kwaye ibonakala njengeoli okanye i-mucilage kwimeko yayo yolwelo. Yinto eqhelekileyo egcina izinto zokuthambisa, kwaye inokufumaneka kuyo yonke into ukusuka kwiikhrimu zobuso ukuya kwiloshini.
I-Phenoxyethanol ifezekisa umphumo wayo wokulondoloza kungekhona nge-antioxidant kodwa ngomsebenzi wayo wokulwa ne-microbial, evimbela kwaye isuse iidosi ezinkulu zegram-positive kunye ne-negative microorganisms. Kwakhona kunempembelelo ebalulekileyo yokuthintela kwiintlobo zebhaktheriya eziqhelekileyo ezifana ne-E. coli kunye ne-Staphylococcus aureus.
Ngaba i-phenoxyethanol iyingozi eluswini?
I-Phenoxyethanol inokubulala xa ifakwe kwiidosi ezinkulu. Nangona kunjalo, ukusetyenziswa kwezihlokophenoxyethanolekugxininiseni ngaphantsi kwe-1.0% isengaphakathi kuluhlu olukhuselekileyo.
Siye saxoxa ngaphambili ukuba i-ethanol i-metabolized kwi-acetaldehyde ngobuninzi obukhulu esikhumbeni kwaye ingaba ifunnwe ngobuninzi esikhumbeni. Zombini ezi zikwabaluleke kakhulu kwiphenoxyethanol. Kulusu olunomqobo ongaguqukiyo, i-phenoxyethanol yenye yezona zinto zikhawulezayo ukuthoba i-glycol ethers. Ukuba i-metabolism ye-phenoxyethanol ifana ne-ethanol, isinyathelo esilandelayo kukubunjwa kwe-acetaldehyde engazinzanga, ilandelwa yi-phenoxyacetic acid kunye nezinye ii-radicals zamahhala.
Sukuba nexhala okwangoku! Xa besixoxa nge-retinol ngaphambili, siphinde sakhankanya inkqubo ye-enzyme ehambelana nemetabolism yephenoxyethanol, kwaye ezi nkqubo zokuguqulwa zenzeka phantsi kwe-stratum corneum. Ke kufuneka sazi ukuba ingakanani na i-phenoxyethanol efunxekayo ngokwenyani. Kolunye uphononongo oluvavanye ukufunxwa kwe-sealant esekelwe emanzini equlethe i-phenoxyethanol kunye nezinye izithako ezichasene ne-microbial, isikhumba sehagu (esona sinamandla okungena ngokukhawuleza ebantwini) sinokufunxa i-2% ye-phenoxyethanol, eyonyuka kuphela kwi-1.4% emva kweeyure ze-6, kunye ne-11.3% emva kweeyure ezingama-28.
Olu phononongo lucebisa ukuba ukufunxwa kunye nokuguqulwa kwephenoxyethanolekugxininiseni ngaphantsi kwe-1% ayiphezulu ngokwaneleyo ukuvelisa iidosi ezinobungozi ze-metabolites. Iziphumo ezifanayo nazo zifunyenwe kwizifundo kusetyenziswa iintsana ezisanda kuzalwa ngaphantsi kweeveki ezingama-27. Uphononongo lwathi, "Aqueousphenoxyethanolayibangeli umonakalo omkhulu wolusu xa kuthelekiswa ne-ethanol-based preservatives. Iphenoxyethanol iyafunxwa eluswini lweentsana ezisandula ukuzalwa, kodwa ayiyikhi imveliso ye-oxidation phenoxyacetic acid ngezixa ezininzi." Esi siphumo sikwabonisa ukuba i-phenoxyethanol inomlinganiselo ophezulu we-metabolism eluswini kwaye ayibangeli umonakalo omkhulu.
Ngubani na ongcono, phenoxyethanol okanye utywala?
Nangona i-phenoxyethanol yenziwe i-metabolized ngokukhawuleza kune-ethanol, i-concentration ephezulu ethintelweyo kwi-topical application ingaphantsi kakhulu kwi-1%, ngoko ayiluthelekiso olulungileyo. Ekubeni i-stratum corneum ithintela uninzi lweeamolekyu ukuba zifakwe, i-radicals yamahhala eyenziwa zezi zimbini zingaphantsi kakhulu kunezo zenziwe yi-oxidation reactions yazo yonke imihla! Ngaphezu koko, ngenxa yokuba i-phenoxyethanol iqulethe amaqela e-phenolic ngendlela yeoli, iyaphuphuma kwaye yome kancinci.
Isishwankathelo
I-Phenoxyethanol sisilondolozi esiqhelekileyo esisetyenziswa kwizinto zokuthambisa. Ikhuselekile kwaye iyasebenza, kwaye yeyesibini kuphela kwiparabens ngokwemigaqo yokusetyenziswa. Nangona ndicinga ukuba i-parabens nayo ikhuselekile, ukuba ufuna iimveliso ngaphandle kweparabens, i-phenoxyethanol lukhetho oluhle!