I-Pharmacodynamics yeChloroxylenol

I-Chloroxylenol, okanye i-para-chloro-meta-xylenol (PCMX), sisixhobo esaziwayo sokubulala iintsholongwane kunye nokubulala iintsholongwane. Sisisixhobo sokucoca esisetyenziswa kwigumbi lesibhedlele ukucoca izixhobo zotyando.

I-Chloroxylenol yenye yezithako ezisebenzayo ezisetyenziswa ekwenzeni isepha yokubulala iintsholongwane. Kwakhona, ukusetyenziswa kwayo kuyasebenza kakhulu kwezonyango nasekhaya njengesibulali-ntsholongwane.

Ngokutsho koLuhlu lweeMithi eziBalulekileyo ze-World Health Organisation, ukuchaphazeleka kwe-chloroxylenol kuhlobo lweebhaktheriya olwaziwa ngokuba yi-Gram-positive, kubhaliwe kakuhle.

Nangona kunjalo, ukuba ufuna i-arhente efanelekileyo yokulwa neentsholongwane kunye ne-disinfectant kwiimfuno zasekhaya nasesibhedlele, kuya kufuneka uqhagamshelane nomntu othembekileyo.i-chloroxylenolumenzi.

Isalathisi se-Chloroxylenol kwi-Pharmacological

Ukusetyenziswa kwe-chloroxylenol kuyabonakala kakhulu kwicandelo lezonyango.

Yayisetyenziswa ngaphambili kunyango lwezifo zesikhumba ezifana nemikrwelo, amanxeba, ukulunywa zizilwanyana, ukuhlatywa, kunye nesicoci sezandla.

I-Pharmacodynamics yeChloroxylenol

I-Chloroxylenolyi-phenol ethatha indawo yayo, oko kuthetha ukuba ineqela le-hydroxyl kwisakhiwo sayo.

Ukusetyenziswa kwayo kwaziwa kakhulu kule minyaka idlulileyo njengenye yezona zinto zisebenzayo kwiimveliso zokubulala iintsholongwane. Ukusetyenziswa kwayo kucetywayo ngaphandle kweseli.

Kuxelwe ukuba umsebenzi wayo wokulwa neentsholongwane ngenani elincinci kwiqela leebhaktheriya.

Indlela Yokusebenza

Ubukho bamaqela e-hydroxyl kwisakhiwo sayo bubaluleke kakhulu, ingakumbi xa kufuneka kuchazwe amandla ayo e-pharmacological.

Kucingelwa ukuba iqela le-hydroxyl linamathela kwiindawo ezibopha iproteni, nto leyo enceda ekuthinteleni intsholongwane ehlaselayo.

I-Chloroxylenol ingena kwiseli yebhaktheriya ukuze ihlasele ngakumbi ngee-enzymes kunye neeproteni ezaneleyo. Xa oku kusenziwa, iyenza kungasebenzi imisebenzi yeseli.

Iya kufikelela kwinqanaba apho inani elikhulu leChloroxylenol lifakwa kwiiseli eziqhekekayo nto leyo ebangela ukufa kwazo.

I-Metabolism yeChloroxylenol

Ukuze kuqinisekiswe ngokufanelekileyo ukuba i-Chloroxylenol iyasebenza njenge-bacterial kunye ne-disinfectant, izilwanyana zisetyenziselwe ukufunda ngokupheleleyo umsebenzi wayo.

Uvavanyo lwezilwanyana lubonise ukuba ngenxa yokusetyenziswa kweChloroxylenol eluswini, izinga lokuntywiliselwa emzimbeni lalikhawuleza kakhulu kwiiyure ezimbini zokuqala.

Kwakhona kwaphawulwa ukuba into eyayinikwa izilwanyana yayichanyelwa ngaphandle ngezintso kwaye isuswe phantse ngokupheleleyo ngesantya seeyure ezingama-24.

Inxalenye ebalulekileyo echongiweyo kwisampuli ekhutshiweyo iquka i-glucuronides kunye ne-sulfates.

Uninzi lwamanqaku ophando malunga neChloroxylenol luthelekise umsebenzi wayo ne-antibacterial eyaziwayo nexhaswa kakhulu ebizwa ngokuba yi-triclosan. Ingxelo ibonise ukuba ii-glucuronides nazo zaziyinxalenye yesampulu yokukhupha iindle kwimodeli yomntu.

Ngaphezu koko, kwisifundo somzekelo womntu, kucingelwa ukuba yonke i-5 mg ethathwa emzimbeni emva koko iya kuchama ukuya kuthi ga kwi-14% ye-glucuronic acid kunye ne-sulfuric acid kwiintsuku ezintathu.

Nangona kunjalo, naluphi na umlinganiselo weChloroxylenol ongeniswe emzimbeni uya kugaywa kamva sisibindi kwaye uchame njenge-sulfate kunye ne-glucuronic derivatives.

Indlela Yokususa

Njengoko kunokubonwa ngasentla kwizifundo ezenziwe ngeChloroxylenol zibonisa ukuba indlela ephambili yokususwa kwe-chloroxylenol kwinkqubo emva kokusetyenziswa kukumchamo.

Nangona kunjalo, inani elincinci kakhulu lithathwa njengelikwinyongo kwaye lincinci kakhulu emoyeni ophefumlayo.

Ngaba udinga iChloroxylenol?

NcedaCofa aphanamhlanje ngenxaI-Chloroxylenolngazo zonke iimveliso zakho zokubulala iintsholongwane kunye neemveliso zokubulala iintsholongwane, kwaye siya kuvuya kakhulu ukusebenzisana nawe ukuze ufumane iimveliso ezilungileyo.