I-Pharmacodynamics yeChloroxylenol

I-Chloroxylenol, okanye i-para-chloro-meta-xylenol (i-PCMX), i-antibacterial eyaziwayo kunye ne-sterilizing agent.Yiarhente yokucoca esetyenziswa kwithiyetha yasesibhedlele ukucoca iikiti zotyando.

I-Chloroxylenol yenye yezinto ezisebenzayo ezisetyenziswa ekwenzeni iisepha ezibulala amagciwane.Kwakhona, usetyenziso lwayo lunqumle kwezonyango kunye nabasemakhaya njengesibulali ntsholongwane.

NgokoLuhlu loMbutho wezeMpilo weHlabathi wamaYeza aBalulekileyo, ukuchaphazeleka kwe-chloroxylenol ngokuchasene nohlobo lwebhaktheriya eyaziwa ngokuba yiGram-positive, kubhalwe kakuhle.

Nangona kunjalo, ngaba ufuna i-antibacterial efanelekileyo kunye ne-arhente yokubulala iintsholongwane kwiimfuno zendlu yakho kunye nesibhedlele, emva koko kufuneka uqhagamshelane nomntu ohloniphekileyo.chloroxylenolumenzi.

Pharmacological Isalathisi seChloroxylenol

Izicelo ze-Chloroxylenol zichazwe kakuhle kwintsimi yezonyango.

Yayisetyenziswa ngaphambili kunyango losulelo lwesikhumba olunje ngemikrwelo, amanxeba, ukulunywa zizilwanyana, ukuhlaba, kunye nesicoci sesandla.

Pharmacodynamics yeChloroxylenol

I-Chloroxylenolyi-phenol yokutshintshwa, okuthetha ukuba ineqela le-hydroxyl kwisakhiwo sayo.

Ukusetyenziswa kwayo kwaziwa kule minyaka idlulileyo njengenye yezinto ezisebenzayo kwiimveliso ezibulala iintsholongwane.Ukusetyenziswa kwayo kucetywayo ngaphandle kweseli.

Umsebenzi wayo we-antimicrobial kwixabiso elincinci kwiqela lebhaktheriya libikwa.

Indlela yokuSebenza

Ubukho bamaqela e-hydroxyl kwisakhiwo sayo bubaluleke kakhulu, ngakumbi xa amandla ayo e-pharmacological kufuneka achazwe.

Iqela le-hydroxyl licingelwa ukuba linamathele kwiindawo ezibophezelayo zeprotheni, oko kukuthi, uncedo ekuthinteleni ibhaktheriya ehlaselayo.

I-Chloroxylenol ingena kwiseli yebhaktiriya ukuze ihlasele ngakumbi ngee-enzymes kunye neeprotheni ezaneleyo.Xa oku kusenziwa, ivala imisebenzi yeseli.

Iya kufikelela kwinqanaba apho isixa esikhulu seChloroxylenol sisetyenziswa kwiiseli zehlwili ezikhokelela ekufeni kwazo.

I-Metabolism yeChloroxylenol

Ukufumana amaxwebhu afanelekileyo eChloroxylenol njenge-bacterial and disinfectant agent, izilwanyana zazisetyenziselwa ukufunda ngokupheleleyo umsebenzi wamandla ayo.

Uvavanyo lwezilwanyana lubonise ukuba ngenxa yokusetyenziswa kwedermal yeChloroxylenol, izinga lokuntywiliselwa lalikhawuleza kakhulu kwiiyure ezimbini zokuqala.

Kwaye kwaphawulwa ukuba into enikwe izilwanyana yakhutshwa ngumchamo kwizintso kwaye isuswe ngokupheleleyo ngesantya seeyure ezingama-24.

Inxalenye ebalulekileyo echongiweyo kwisampuli ekhutshiweyo iquka i-glucuronides kunye ne-sulfates.

Uninzi lwamanqaku ophando malunga neChloroxylenol ithelekisa umsebenzi wayo kunye ne-antibacterial eyaziwayo kunye ne-antibacterial ebizwa ngokuba yi-triclosan.Ingxelo ibonise ukuba i-glucuronides nayo yayiyinxalenye yesampulu ekhutshwe kwimodeli yomntu.

Ngaphezu koko, kuphononongo lwemodeli yomntu, kwacingelwa ukuba yonke i-5 mg ethatyathwe emzimbeni iya kuthi emva koko ichame ukuya kuthi ga kwi-14% ye-glucuronic acid kunye ne-sulfuric acid kwiintsuku ezintathu.

Nangona kunjalo, nayiphi na isixa seChloroxylenol esithathwe kwisistim siya kuthi kamva sigaywe sisibindi kwaye sichanywe njenge-sulfate kunye ne-glucuronic derivatives.

Indlela Yokuphelisa

Njengoko kunokubonwa ngasentla kwizifundo eziqhutywe ngeChloroxylenol zibonisa ukuba eyona ndlela iphambili i-chloroxylenol isuswa ngayo kwinkqubo emva kokulawulwa ngumchamo.

Nangona, inani elincinci kakhulu lithathwa ukuba likwi-bile kunye nexabiso elincinci kakhulu emoyeni ophefumlelweyo.

Ngaba uyafuna iChloroxylenol?

NgobubeleCofa aphanamhlanje ngenxaI-Chloroxylenolkuzo zonke iimveliso zakho ze-antiseptic kunye nezibulala-zintsholongwane, kwaye siya kuvuya kakhulu ukusebenzisana nawe ngezona mveliso zibalaseleyo.