Yayikade yaziwa ngokuba "yigolide emhlophe", kwaye igama layo lilele kwisiphumo sayo sobumhlophe obungenakuthelekiswa nanto kwelinye icala, kunye nobunzima kunye nokunqongophala kokutsalwa kwayo kwelinye.Isityalo se-Glycyrrhiza glabra ngumthombo we-Glabridin, kodwa i-Glabridin kuphela i-akhawunti ye-0.1% -0.3% yomxholo wayo wonke, oko kukuthi, i-1000kg ye-Glycyrrhiza glabra inokufumana kuphela i-100g yeGlabridin, I-1g ye-Glabridin ilingana ne-1g yegolide ebonakalayo.
I-Hikarigandine ngummeli oqhelekileyo wezithako zemifuno, kwaye umphumo wayo wobumhlophe ufunyenwe yiJapan
IGlycyrrhiza glabra sisityalo sohlobo lweGlycyrrhiza.I-China lilizwe elinezona zixhobo zityebileyo zamayeza emhlabeni, kwaye kukho ngaphezu kwe-500 iintlobo zezityalo ezisetyenziswa kwikliniki, phakathi kwazo eyona isetyenziswa kakhulu yi-licorice.Ngokwezibalo, izinga lokusetyenziswa kwe-licorice lingaphezulu kwe-79%.
Ngenxa yembali ende yesicelo, ehamba kunye nodumo oluphezulu, ububanzi bophando malunga nexabiso le-licorice alizange liphule kuphela kwimida yendawo, kodwa isicelo sandisiwe.Ngokutsho kophando, abathengi base-Asiya, ngakumbi eJapan, banentlonipho enkulu kwizithambiso ezinezithako ezisebenzayo zamayeza.I-114 yezithako zokuthambisa zamakhambi ziye zarekhodwa "kwi-Japan's General Cosmetics Raw Materials", kwaye sele kukho iindidi ezingama-200 zezithambiso ezinezithako zamayeza eJapan.
Iqondwa ukuba inefuthe elimhlophe kakhulu, kodwa yintoni ubunzima ekusebenziseni okusebenzayo?
Inxalenye ye-hydrophobic ye-licorice extract iqulethe iindidi ze-flavonoids.Njengenxalenye ephambili yecandelo layo le-hydrophobic, i-halo-glycyrrhizidine inempembelelo yokuthintela kwimveliso ye-melanin kwaye inefuthe elichasayo kunye ne-anti-oxidant.
Ezinye iinkcukacha zovavanyo zibonisa ukuba i-whitening effect ye-Glabridin yokukhanya ngamaxesha angama-232 aphezulu kune-vitamin C eqhelekileyo, amaxesha angama-16 aphezulu kune-hydroquinone, kunye namaxesha e-1,164 aphezulu kune-arbutin.Kwindlela yokufezekisa umsebenzi oqinileyo wokuqaqamba, ukukhanya kweGlabridin kunika iindlela ezintathu ezahlukeneyo.
1. Ukuvinjelwa komsebenzi we-tyrosinase
Eyona ndlela yokwenza mhlophe yeGlabridinkukuthintela ukudityaniswa kwe-melanin ngokhuphisana ngokunqanda umsebenzi we-tyrosinase, ukususa inxalenye ye-tyrosinase kwiringi ye-catalytic ye-melanin synthesis kunye nokuthintela ukubophelela kwe-substrate kwi-tyrosinase.
2. Isiphumo se-Antioxidant
Inokuthintela zombini umsebenzi we-tyrosinase kunye ne-dopa pigment interchange kunye nomsebenzi we-dihydroxyindole carboxylic acid oxidase.
Kuye kwaboniswa ukuba kwi-concentration ye-0.1mg / ml, i-photoglycyrrhizidine inokusebenza kwi-cytochrome P450 / NADOH inkqubo ye-oxidation kunye ne-scavenge i-67% ye-radicals yamahhala, enomsebenzi onamandla we-antioxidant.
3.Inhibit izinto ezivuthayo kunye nokulwa ne-UV
Okwangoku, uphando oluncinci luye lwabikwa malunga nokusetyenziswa kwe-photoglycyrrhizidine kwisifundo se-UV-induced skin photoaging.Ngo-2021, kwinqaku elikwijenali yeMicrobiology kunye ne-Biotechnology, i-photoglycyrrhizidine liposomes yafundelwa ukukwazi ukuvuselela i-erythema ebangelwa ukukhanya kwe-UV kunye nesifo solusu ngokuthintela izinto ezivuthayo.I-Photoglycyrrhizidine liposomes ingasetyenziselwa ukuphucula i-bioavailability kunye ne-cytotoxicity encinci kunye ne-melanin inhibition engcono, ukunciphisa ngokufanelekileyo ukubonakaliswa kwe-cytokines evuthayo, i-interleukin 6 kunye ne-interleukin 10. Ngoko ke, inokusetyenziswa njenge-agent yonyango yonyango ukuchasana nomonakalo wesikhumba obangelwa yi-UV. ngokuthintela ukudumba, okunokubonelela ngeembono ezithile kuphando lweemveliso zokukhusela ukukhanya kwelanga.
Isishwankathelo, isiphumo esimhlophe se-photoglycyrrhizidine sibonwa, kodwa ubume bayo buphantse bungabi namanzi, ngoko bufuna ngokukodwa ukuveliswa kunye nenkqubo yokuvelisa kwisicelo sokongeza imveliso yokunakekelwa kwesikhumba, kwaye okwangoku sisisombululo esihle nge-liposome. iteknoloji ye-encapsulation.Ngaphezu koko, ifotoGlabridini-liposomes inokuthintela i-UV-induced photoaging, kodwa lo msebenzi ufuna iimvavanyo ezininzi zeklinikhi ukuze ziqinisekiswe kwaye izicelo zophando ziphunyezwe.
Iimveliso zokunakekelwa kwesikhumba eziqulethe ifotoGlabridin ngendlela yokudibanisa isithako.
Nangona kungekho mathandabuzo ukuba ifotoGlabridine inesiphumo esihle kakhulu sokwenza mhlophe, ixabiso layo lezinto eziluhlaza likwanqatshelwe ngenxa yobunzima bokukhutshwa kunye nomxholo.Kwi-R & D ye-cosmetic, umsebenzi wokulawula iindleko udibene ngokuthe ngqo nomxholo wezobuchwepheshe kunye nenkqubo yesayensi.Ngoko ke, kuyindlela efanelekileyo yokulawula iindleko zokuqulunqa kunye nokufezekisa umgangatho okhuselekileyo kunye osebenzayo ngokukhetha izithako ezisebenzayo kunye nokudibanisa ngokudibanisa ne-photoglycyrrhizidine.Ukongeza kwinqanaba le-R & D, uphando olongezelelweyo luyafuneka malunga nophando lwe-photoglycyrrhizidine liposomes kunye neendlela zamva nje zokukhupha.
Ixesha lokuposa: Aug-30-2022