I-Triclosanyi-antimicrobial ebanzi esetyenziswa njenge-antiseptic, i-disinfectant okanye i-preservative kwiindawo zonyango, iimveliso ezahlukeneyo zabathengi kuquka izinto zokuthambisa, iimveliso zokucoca indlu, izinto zeplastiki, izinto zokudlala, iipeyinti, njl. Ikwafakwa kumphezulu wezixhobo zonyango, izinto zeplastiki, amalaphu, izixhobo zasekhitshini, njl., apho inokuphuma kancinci ixesha elide ngexesha lokusetyenziswa kwazo, ukuze yenze umsebenzi wayo wokubulala iintsholongwane.
Isetyenziswa njani i-triclosan kwizinto zokuthambisa?
I-Triclosanyadweliswa ngo-1986 kwi-European Community Cosmetics Directive ukuze isetyenziswe njengesigcini kwiimveliso zezithambiso kumanqanaba afikelela kwi-0.3%. Uvavanyo lwakutshanje lomngcipheko olwenziwe yiKomiti yeSayensi ye-EU yeeMveliso zaBathengi lugqibe kwelokuba, nangona ukusetyenziswa kwayo kumanqanaba aphezulu e-0.3% kwii-toothpastes, iisepha zezandla, iisepha zomzimba/ii-gel zeshawa kunye nee-deodorant sticks kwakuthathwa njengokukhuselekileyo ngokwembono yetyhefu kwiimveliso nganye, ubungakanani bokuvezwa ngokupheleleyo kwi-triclosan kuzo zonke iimveliso zezithambiso abukhuselekanga.
Nakuphi na ukusetyenziswa okongezelelweyo kwe-triclosan kwiimpuphu zobuso kunye nezinto zokufihla amabala kule ngxubevange nako kwathathwa njengokukhuselekileyo, kodwa ukusetyenziswa kwe-triclosan kwezinye iimveliso zokuyeka (umz. iiloshini zomzimba) nakwiindawo zokuhlamba umlomo kwakuthathwa njengokukhuselekileyo kumthengi ngenxa yokuvezwa okuphezulu okubangelwa kuko. Ukuvezwa kwi-triclosan ekuphefumlweni okuvela kwiimveliso zokutshiza (umz. ii-deodorants) akuzange kuhlolwe.
I-TriclosanEkubeni ingena-ionic, inokwenziwa kwii-dentifrices zesiqhelo. Nangona kunjalo, ayibopheleleki kwiindawo zomlomo kangangeeyure ezimbalwa, kwaye ngenxa yoko ayiniki nqanaba elihlala lihleli lomsebenzi wokulwa ne-plaque. Ukwandisa ukufunxwa kunye nokugcinwa kwe-triclosan kwiindawo zomlomo ukuphucula ulawulo lwe-plaque kunye nempilo ye-gingival, kusetyenziswa i-triclosan/polyvinylmethyl ether maleic acid copolymer kunye ne-triclosan/zinc citrate kunye ne-triclosan/calcium carbonate dentifrice.
Isetyenziswa njani i-triclosan kwizixhobo zonyango nakwizixhobo zonyango?
I-TriclosanIsetyenziswe ngempumelelo kwiklinikhi ukuphelisa iintsholongwane ezifana ne-methicillin-resistant Staphylococcus aureus (MRSA), ngakumbi ngengcebiso yokusebenzisa i-2% ye-triclosan bath. I-Triclosan isetyenziswa njenge-scrubs yotyando, kwaye isetyenziswa kakhulu ekuhlambeni izandla nanjengokuhlamba umzimba ukuphelisa i-MRSA kubantu abathwala le ntsholongwane ngaphambi kotyando.
I-Triclosan isetyenziswa kwizixhobo ezininzi zonyango, umzekelo, ii-stents ze-ureteral, ii-sutures zotyando kwaye zinokuthathwa njengezithintela usulelo lwe-graft. UBojar nabanye abazange babone umahluko ekungeneni kwe-colonization phakathi kwee-sutures ezigqunywe yi-triclosan kunye ne-multifilament suture eqhelekileyo, nangona umsebenzi wabo wawuphathelele iibhaktheriya ezintlanu kwaye usekelwe kuphela ekumiselweni kwendawo yokuthintela.
Kwi-ureteral stents, i-triclosan ibonakalisiwe ukuba iyathintela ukukhula kwe-uropathogens yebhaktheriya eqhelekileyo kwaye inciphisa ukwanda kwezifo zomchamo, kwaye mhlawumbi, i-catheter encrustation ibonakalise kutshanje iziphumo ze-triclosan kunye nee-antibiotics ezifanelekileyo kwi-isolates zeklinikhi eziquka iintlobo ezisixhenxe ze-uropathogenic, kwaye zixhasa ukusetyenziswa kwe-triclosan-eluting stent xa kuyimfuneko, kunye nonyango oluqhelekileyo lwe-antibiotic ekunyangeni izigulana ezinzima.
Kwezinye izinto eziqhubekayo, ukusetyenziswa kwe-triclosan kwi-catheter ye-Foley yomchamo kwacetyiswa kuba i-triclosan yathintela ngempumelelo ukukhula kwe-Proteus mirabilis kunye nokulawulwa kokufakwa kunye nokuvaleka kwe-catheter. Kutshanje, uDarouiche et al. babonakalise umsebenzi we-synergistic, wide-spectrum kunye ne-antimicrobial ohlala ixesha elide we-catheters ezigqunywe yindibaniselwano ye-triclosan kunye ne-DispersinB, i-enzyme ye-anti-biofilm ethintela kwaye isasaze i-biofilms.
Isetyenziswa njani i-triclosan kwezinye iimveliso zabathengi?
Umsebenzi we-triclosan wokulwa neentsholongwane obanzi ukhokelele ekubeni ifakwe kuluhlu olubanzi lweemveliso ezenzelwe ukusetyenziswa ekhaya ezifana nesepha zolwelo, izicoci, iibhodi zokunqunqa, izinto zokudlala zabantwana, iikhaphethi kunye nezikhongozeli zokugcina ukutya. Uluhlu oluneenkcukacha lweemveliso zabathengi ezine-triclosan lubonelelwa yi-US Environmental Protection Agency (EPA) kunye nee-NGOs zase-US "Environmental Working Group" kunye ne-"Beyond Pesticides".
Inani elikhulayo lempahla yokunxiba liphathwa nge-biocides. I-Triclosan yenye yezinto zokugqiba imveliso yempahla enjalo. Iimpahla ezigqitywe nge-triclosan ziphathwa ngee-agents ezidibanisayo ukuze zibonelele ngeempawu zokulwa nentsholongwane ezihlala ixesha elide. Ngokusekelwe kulwazi olufumanekayo, iimveliso ezili-17 ezivela kwimarike yokuthengisa yaseDenmark zahlalutywa ukuze kujongwe umxholo wezinye izinto ezikhethiweyo ze-antibacterial: i-triclosan, i-dichlorophen, i-Kathon 893, i-hexachlorophen, i-triclocarban kunye ne-Kathon CG. Ezintlanu zeemveliso zifunyenwe ziqulathe i-0.0007% - 0.0195% ye-triclosan.
U-Aiello nabanye kuphononongo lokuqala olucwangcisiweyo oluvavanya inzuzo yesepha ezine-triclosan, bavavanya izifundo ezingama-27 ezapapashwa phakathi kowama-1980 nowama-2006. Esinye seziphumo eziphambili kukuba isepha ezazine-triclosan engaphantsi kwe-1% azizange zibone nzuzo kwiisepha ezingezizo iintsholongwane. Izifundo ezisebenzise isepha equlethe i-triclosan engaphezulu kwe-1% zibonise ukwehla okukhulu kwamanqanaba eebhaktheriya, rhoqo emva kokusetyenziswa izihlandlo ezininzi.
Ukungabikho kobudlelwane obucacileyo phakathi kokusetyenziswa kwesepha ene-triclosan kunye nokunciphisa izifo ezosulelayo bekunzima ukuqiniseka ngaphandle kokuchongwa kwezinto eziphilayo ezibangela iimpawu zesifo. Izifundo ezimbini zakutshanje zase-US zibonise ukuba ukuhlamba izandla ngesepha yokulwa neentsholongwane ene-triclosan (0.46%) kunciphisa umthwalo weentsholongwane kunye nokudluliselwa kweentsholongwane ezandleni, xa kuthelekiswa nokuhlamba izandla ngesepha engenazo iintsholongwane.
Iimveliso zaseNtwasahlobo
Sivelisa uluhlu olubanzi lweemveliso ezinokusetyenziswa kwishishini lokhathalelo lomntu kunye nobuhle, njengokhathalelo lolusu, ukhathalelo lweenwele, ukhathalelo lomlomo, izinto zokuthambisa, ukucoca indlu, ukhathalelo lwesepha kunye nokuhlamba impahla, ukucoca izibhedlele kunye neziko likarhulumente. Qhagamshelana nathi ngoku ukuba ufuna iqabane leshishini elithembekileyo.
Ixesha lokuthumela: Juni-10-2021