Triclosani-antimicrobial spectrum ebanzi esetyenziswa njenge-antiseptic, i-disinfectant okanye i-preservative kwimimiselo yeklinikhi, iimveliso ezahlukeneyo zabathengi ezibandakanya izinto zokuthambisa, iimveliso zokucoca indlu, izinto zeplastiki, iithoyi, iipeyinti, njl. impahla, izixhobo zasekhitshini, njl.njl., apho inokuphuma kancinane ixesha elide ngexesha lokusetyenziswa kwazo, ukwenza isenzo sayo se-biocidal.
Isetyenziswa njani i-triclosan kwizinto zokuthambisa?
Triclosanyadweliswa kwi-1986 kwi-European Community Cosmetics Directive ukuze isetyenziswe njengento yokukhusela kwiimveliso ze-cosmetic ekugxininiseni ukuya kwi-0.3%.Uvavanyo lwamva nje lomngcipheko olwenziwa yiKomiti yeSayensi ye-EU yeeMveliso zaBathengi lugqibe kwelokuba, nangona ukusetyenziswa kwayo kugxininiso oluphezulu lwe-0.3% kwintlama yamazinyo, isepha yesandla, isepha yomzimba/ijeli zeshawa kunye nezinti zokukhupha ivumba elithathwa njengekhuselekile kwindawo yokujonga ityhefu. iimveliso zomntu ngamnye, ubukhulu be-aggregate exposure kwi-triclosan evela kuzo zonke iimveliso zokuthambisa akukhuselekanga.
Nakuphi na ukusetyenziswa okongeziweyo kwe-triclosan kumgubo wobuso kunye nezinto zokufihla amabala kolu gxininiso nako kujongwe kukhuselekile, kodwa ukusetyenziswa kwetriclosan kwezinye iimveliso zekhefu (umz. izithambiso zomzimba) kunye nokuhlamba umlomo akuzange kuthathwe njengokukhuselekileyo kumthengi ngenxa yokuphakama okuphezulu ukutyhileka.Ukuchaneka ngokuphefumla kwi-triclosan kwiimveliso zokutshiza (umz. iideodorants) akuzange kuhlolwe.
Triclosanekubeni i-non-ionic, inokuqulunqwa kwii-dentfrices eziqhelekileyo.Nangona kunjalo, ayibopheleli kwiindawo zomlomo ngaphezu kweeyure ezimbalwa, kwaye ngoko ke ayinikezeli inqanaba elizinzileyo lomsebenzi we-anti-plaque.Ukwandisa ukunyuswa kunye nokugcinwa kwe-triclosan ngeendawo zomlomo zokuphucula ulawulo lwe-plaque kunye nempilo ye-gingival, i-triclosan / polyvinylmethyl ether maleic acid copolymer kunye ne-triclosan / zinc citrate kunye ne-triclosan / calcium carbonate dentifrice zisetyenziswa.
Isetyenziswa njani i-triclosan kukhathalelo lwempilo kunye nezixhobo zonyango?
Triclosanisetyenziswe ngokufanelekileyo eklinikhi ukuphelisa izilwanyana ezincinci ezifana ne-methicillin-resistant Staphylococcus aureus (MRSA) , ngokukodwa kunye nesincomo sokusebenzisa i-2% ye-triclosan bath.I-Triclosan isetyenziswa njengezikhuhla zotyando, kwaye isetyenziswa kakhulu ekuhlambeni izandla nanjengokuhlamba umzimba ukuphelisa i-MRSA kubathwali ngaphambi kotyando.
I-Triclosan isetyenziswa kwiqela lezixhobo zonyango, umzekelo izinti ze-ureteral, iintsimbi zotyando kwaye zinokugqalwa njengokuthintela usulelo lokuxhunyelelwa.U-Bojar et al akazange abone umehluko kwikholoni phakathi kwe-triclosan-coated sutures kunye ne-multifilament suture eqhelekileyo, nangona umsebenzi wabo ujongene neebhaktheriya ezintlanu kwaye usekelwe kuphela ekumiselweni kwendawo yokuthintela.
Kwi-stents ye-ureter, i-triclosan ibonakaliswe ukuba inqanda ukukhula kwe-uropathogens yebhaktheriya eqhelekileyo kunye nokunciphisa iziganeko ze-urinary-tract infections kwaye, mhlawumbi, i-catheter encrustation ibonise imiphumo ye-synergistic ye-triclosan kunye ne-antibiotics efanelekileyo kwiikliniki ezizimeleyo ezibandakanya iintlobo ezisixhenxe ze-uropathogenic, kwaye bayakuxhasa ukusetyenziswa kwe-triclosan-eluting stent xa kuyimfuneko, kunye nonyango oluqhelekileyo lokubulala iintsholongwane ekunyangeni izigulana ezintsokothileyo.
Kolunye uphuhliso olongezelelweyo, ukusetyenziswa kwe-triclosan kumchamo we-Foley catheter kwacetyiswa kuba i-triclosan ithintele ngempumelelo ukukhula kwe-Proteus mirabilis kunye nokulawulwa kwe-encrustation kunye nokuvaleka kwe-catheter.Kutshanje, uDarouiche et al.ibonise umsebenzi we-synergistic, i-spectrum ebanzi kunye nesigxina se-antimicrobial ye-catheters ehlanganiswe ne-triclosan kunye ne-DispersinB, i-anti-biofilm enzyme evimbela kwaye isasaze i-biofilms.
Isetyenziswa njani i-triclosan kwezinye iimveliso zabathengi?
Umsebenzi obanzi we-antimicrobial we-triclosan ukhokelele ekudityanisweni kwayo kuluhlu olwandisiweyo lwemveliso elungiselelwe ukusetyenziswa ekhaya njengesepha engamanzi, izinto zokucoca, iibhodi zokunqunqa, iithoyi zabantwana, iikhaphethi kunye nezitya zokugcina ukutya.Uluhlu olucacileyo lweemveliso zabathengi eziqukethe i-triclosan lunikezelwa yi-Arhente ye-Environmental Protection Agency (EPA) yase-US kunye nee-NGOs zase-US "Iqela eliSebenzayo leNdalo" kunye "Ngaphaya kwePesticides" .
Inani elikhulayo lamanqaku empahla aphathwa nge-biocides.I-Triclosan yenye yee-arhente zokugqiba ukuveliswa kweempahla ezinjalo .Iindwangu ezigqityiweyo nge-triclosan ziphathwa nge-cross-linking agents ukubonelela ngeempawu ze-antibacterial ezomeleleyo.Ngokwesiseko solwazi olukhoyo, iimveliso ze-17 ezivela kwimarike yokuthengisa yaseDenmark zahlalutywa kumxholo wezinye iikhompawundi ezikhethiweyo ze-antibacterial: i-triclosan, i-dichlorophen, i-Kathon 893, i-hexachlorophen, i-triclocarban kunye ne-Kathon CG.Ezintlanu zeemveliso zifunyenwe ziqulethe i-0.0007% - 0.0195% triclosan.
U-Aiello et al kuhlaziyo lokuqala olucwangcisiweyo lokuvavanya inzuzo yeesepha eziqukethe i-triclosan, ivavanye izifundo ze-27 ezipapashwe phakathi kwe-1980 kunye ne-2006. Esinye seziphumo eziphambili kukuba iisepha eziqulethe ngaphantsi kwe-1% ye-triclosan ibonise ukuba akukho nzuzo kwiisepha ezingenazo i-antimicrobial.Uphononongo olusebenzise isepha equlathe > i-1% ye-triclosan lubonise ukuhla okubonakalayo kumanqanaba ebhaktiriya esandleni, rhoqo emva kokufakwa kwezicelo ezininzi.
Ukungabikho okubonakalayo kobudlelwane phakathi kokusetyenziswa kwesepha equlethe i-triclosan kunye nokunciphisa izigulo ezosulelayo kwakunzima ukuqiniseka ngokungabikho kokuchongwa kwee-arhente zebhayoloji ezinoxanduva lweempawu zokugula.Amaphononongo amabini akutshanje ase-US abonise ukuba ukuhlamba izandla ngesepha ye-antimicrobial ene-triclosan (0.46%) kwehlisa umthwalo webhaktiriya kunye nokudluliselwa kwebhaktheriya ezandleni, xa kuthelekiswa nokuhlamba izandla ngesepha engeyo-antimicrobial.
Iimveliso zaseNtwasahlobo
Sivelisa uluhlu olubanzi lweemveliso ezinokuthi zisetyenziswe kukhathalelo lomntu kunye neshishini lokuthambisa, njengokhathalelo lwesikhumba, ukhathalelo lweenwele, ukhathalelo lomlomo, izithambiso, ukucocwa kwendlu, isicoci kunye nokuhlamba iimpahla, ukucocwa kwesibhedlele kunye neziko likarhulumente.Qhagamshelana nathi ngoku ukuba ufuna iqabane elithembekileyo kwishishini.
Ixesha lokuposa: Jun-10-2021